新冠康复个体中的CD8 + T细胞反应靶向多种主要新冠病毒流行变体的保守表位。
CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants.
作者信息
Redd Andrew D, Nardin Alessandra, Kared Hassen, Bloch Evan M, Pekosz Andrew, Laeyendecker Oliver, Abel Brian, Fehlings Michael, Quinn Thomas C, Tobian Aaron A R
机构信息
Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Open Forum Infect Dis. 2021 Mar 30;8(7):ofab143. doi: 10.1093/ofid/ofab143. eCollection 2021 Jul.
This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.
本研究检测了2019冠状病毒病康复个体（n = 30）的CD8+ T细胞反应是否有可能维持对主要的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体（α、β、γ；评估了n = 45个突变）的识别。在β变体刺突蛋白中发现的仅有1个突变与先前鉴定的表位重叠（1/52），这表明几乎所有抗SARS-CoV-2 CD8+ T细胞反应应该能够识别这些新描述的变体。
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