Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
J Med Virol. 2020 Sep;92(9):1634-1636. doi: 10.1002/jmv.25773. Epub 2020 Mar 27.
The emergence of the novel betacoronavirus, recently renamed as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised serious concerns due to the virus's rapid dissemination worldwide. Nevertheless, there is limited information about the genomic epidemiology of SARS-CoV-2 circulating in Italy from surveillance studies. The shortage of complete genomic sequences available impairs our understanding of the SARS-CoV-2 introduction and establishment in the country. To better understand its dynamics in Italy, we analyzed complete genomes of SARS-CoV-2 isolates, obtained directly from clinical samples. Our phylogenetic reconstructions suggest possible multiple introduction of SARS-CoV-2. Continued genomic surveillance strategies are needed to improve monitoring and understanding of the current SARS-CoV-2 epidemics, which might help to attenuate public health impact of infectious diseases.
新型贝塔冠状病毒的出现，最近更名为严重急性呼吸综合征冠状病毒 2（SARS-CoV-2），由于该病毒在全球范围内迅速传播，引起了严重关注。然而，从监测研究中，有关在意大利传播的 SARS-CoV-2 的基因组流行病学的信息有限。可用的完整基因组序列的缺乏阻碍了我们对 SARS-CoV-2 在该国的引入和建立的理解。为了更好地了解其在意大利的动态，我们直接从临床样本中分析了 SARS-CoV-2 分离株的完整基因组。我们的系统发育重建表明，SARS-CoV-2 可能存在多次引入。需要继续进行基因组监测策略，以改善对当前 SARS-CoV-2 流行的监测和理解，这可能有助于减轻传染病对公共卫生的影响。
