Ansari Ramandi Mohammad Mostafa, Yarmohammadi Hossein, Beikmohammadi Somayeh, Hosseiny Fahimi Behzad Hassan, Hatami Farbod, Beydokhti Hossein, Bakhshandeh Hooman, Naderi Nasim
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Medical Students Research Committee, Shahed University, Tehran, Iran.
J Cardiovasc Thorac Res. 2021;13(2):92-101. doi: 10.34172/jcvtr.2021.29. Epub 2021 Apr 24.
Manifestations caused by coronavirus family have presented it in many ways during the previous years. The aim of this systematic review was to gather all possible cardiovascular manifestations of the coronavirus family in the literature. Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed, Scopus, Web of Science, Cochrane and ProQuest which were updated on May 1, 2020 for the last time. Regarding to the novelty and speed of publications on COVID-19, we searched Google Scholar and also references of included studies and review articles in the systematic search results were searched manually. The searched keywords were the combination of the following MeSH terms: "COVID-19", "SARS", "MERS" and "cardiovascular presentation". The systematic review was registered with ID CRD42020180736 in International Prospective Register of Systematic Reviews (PROSPERO). After screening, 28 original articles and ten case studies (five case reports and five case series) were included. Most of the studies were focused on COVID-19 (20 original articles and four case studies) while the only studies about Middle East Respiratory Syndrome (MERS) were a case report and a case series. Almost all the cardiovascular presentations and complications including acute cardiac injury, arrhythmias and the thrombotic complications were more prevalent in COVID-19 than severe acute respiratory syndrome (SARS) and MERS. The cardiac injury was the most common cardiovascular presentation and complication in COVID-19 whereas thrombotic complications were commonly reported in SARS. The cardiac injury was the predictor of disease severity and mortality in both COVID-19 and SARS.Coronavirus 2019 may present with cardiovascular manifestations and complications in signs and symptoms, laboratory data and other paraclinical findings. Also, cardiovascular complications in the course of COVID-19 may result in worse outcomes.
在过去几年中，冠状病毒家族引发的症状呈现出多种形式。本系统评价的目的是收集文献中冠状病毒家族所有可能的心血管表现。我们遵循系统评价和Meta分析的首选报告项目（PRISMA）指南，检索了PubMed、Scopus、科学网、Cochrane和ProQuest，这些数据库于2020年5月1日最后一次更新。鉴于关于2019冠状病毒病（COVID-19）的出版物新颖且发表速度快，我们还检索了谷歌学术，并且手动检索了系统搜索结果中纳入研究和综述文章的参考文献。检索关键词是以下医学主题词（MeSH）的组合：“COVID-19”、“严重急性呼吸综合征（SARS）”、“中东呼吸综合征（MERS）”和“心血管表现”。该系统评价在国际系统评价前瞻性注册库（PROSPERO）中注册，注册号为CRD42020180736。筛选后，纳入了28篇原创文章和10个病例研究（5篇病例报告和5篇病例系列）。大多数研究聚焦于COVID-19（20篇原创文章和4个病例研究），而关于中东呼吸综合征（MERS）的唯一研究是1篇病例报告和1篇病例系列。几乎所有的心血管表现和并发症，包括急性心脏损伤、心律失常和血栓形成并发症，在COVID-19中比严重急性呼吸综合征（SARS）和MERS更常见。心脏损伤是COVID-19中最常见的心血管表现和并发症，而血栓形成并发症在SARS中较为常见。心脏损伤是COVID-19和SARS中疾病严重程度和死亡率的预测指标。2019冠状病毒病可能在体征和症状、实验室数据及其他辅助检查结果方面出现心血管表现和并发症。此外，COVID-19病程中的心血管并发症可能导致更差的预后。
