Faculty of Medical Sciences, Department of Pharmacy, University of Kragujevac, Kragujevac, Serbia.
Faculty of Medical Sciences, Department of Physiology, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia.
Mol Cell Biochem. 2021 Nov;476(11):4167-4175. doi: 10.1007/s11010-021-04225-y. Epub 2021 Jul 29.
The aim of our study was to investigate the effects of one-month consumption of polyphenol-rich standardized Aronia melanocarpa extract (SAE) on redox status in anemic hemodialysis patients. The study included 30 patients (Hb < 110 g/l, hemodialysis or hemodiafiltration > 3 months; > 3 times week). Patients were treated with commercially available SAE in a dose of 30 ml/day, for 30 days. After finishing the treatment blood samples were taken to evaluate the effects of SAE on redox status. Several parameters of anemia and inflammation were also followed. After the completion of the treatment, the levels of superoxide anion radical and nitrites significantly dropped, while the antioxidant capacity improved via elevation of catalase and reduced glutathione. Proven antioxidant effect was followed by beneficial effects on anemia parameters (increased hemoglobin and haptoglobin concentration, decreased ferritin and lactate dehydrogenase concentration), but SAE consumption didn't improve inflammatory status, except for minor decrease in C-reactive protein. The consumption of SAE regulates redox status (reduce the productions of pro-oxidative molecules and increase antioxidant defense) and has beneficial effects on anemia parameters. SAE could be considered as supportive therapy in patients receiving hemodialysis which are prone to oxidative stress caused by both chronic kidney disease and hemodialysis procedure. Additionally, it could potentially be a good choice for supplementation of anemic hemodialysis patients. TRN: NCT04208451 December 23, 2019 "retrospectively registered".
本研究旨在探讨食用富含多酚的标准化黑树莓提取物（SAE）一个月对贫血血液透析患者氧化还原状态的影响。该研究纳入了 30 名患者（Hb<110g/l，血液透析或血液透析滤过>3 个月；>3 次/周）。患者接受市售 SAE 治疗，剂量为 30ml/天，持续 30 天。治疗结束后采集血样，评估 SAE 对氧化还原状态的影响。同时还监测了贫血和炎症的几个参数。治疗结束后，超氧阴离子自由基和亚硝酸盐的水平显著下降，而过氧化氢酶和还原型谷胱甘肽的抗氧化能力提高。抗氧化作用的结果是贫血参数的改善（血红蛋白和触珠蛋白浓度升高，铁蛋白和乳酸脱氢酶浓度降低），但 SAE 消耗并没有改善炎症状态，除了 C-反应蛋白略有下降。SAE 调节氧化还原状态（减少促氧化分子的产生，增加抗氧化防御），对贫血参数有有益的影响。SAE 可被视为接受血液透析治疗的患者的辅助治疗，这些患者易受到慢性肾脏病和血液透析过程引起的氧化应激的影响。此外，对于贫血血液透析患者的补充，SAE 也可能是一个不错的选择。TRN：NCT04208451 2019 年 12 月 23 日“回顾性注册”。
