Kanno J, Matsuoka C, Furuta K, Onodera H, Maekawa A, Hayashi Y
Division of Pathology, National Institute of Hygienic Sciences, Tokyo, Japan.
Toxicol Pathol. 1987;15(4):439-43. doi: 10.1177/019262338701500408.
Testes of untreated F344 and Wistar rats in the control groups of carcinogenicity studies were histologically examined, and the histopathological characteristics and histogenesis of glandular changes in these testes were studied. In 266 testes of 2-year-old F344 rats, 263 had interstitial cell tumors (ICTs) (98.9%) and 39 had glandular changes (14.7%). These glandular changes were also found in 1 out of 38 1-year-old F344 rat testes (2.6%), and 3 in 154 2-year-old Wistar rat testes (1.9%). The changes were observed exclusively in the interstitial cell tumors (ICTs). These glandular changes showed variation in size, shape and number. They were composed of tubules or cysts lined by a layer of cuboidal or columnar epithelial cells, which had terminal bars, occasionally PAS- and alcian blue-positive brush borders, and rarely, alcian blue-positive cytoplasmic vacuoles. Serial sections revealed that the changes were not connected with the rete testes, but with the degenerative seminiferous tubules involved in the ICTs lined by a layer of flat endothelial-like cells. The findings suggest that the lesions constitute metaplastic changes of the Sertoli cells.
对致癌性研究对照组中未经处理的F344和Wistar大鼠的睾丸进行了组织学检查，并研究了这些睾丸中腺体变化的组织病理学特征和组织发生。在266个2岁F344大鼠的睾丸中，263个有间质细胞瘤（ICTs）（98.9%），39个有腺体变化（14.7%）。在38个1岁F344大鼠睾丸中的1个（2.6%）以及154个2岁Wistar大鼠睾丸中的3个（1.9%）也发现了这些腺体变化。这些变化仅在间质细胞瘤（ICTs）中观察到。这些腺体变化在大小、形状和数量上存在差异。它们由一层立方或柱状上皮细胞衬里的小管或囊肿组成，这些上皮细胞有终末棒，偶尔有PAS和阿尔辛蓝阳性的刷状缘，很少有阿尔辛蓝阳性的细胞质空泡。连续切片显示，这些变化与睾丸网无关，而是与由一层扁平内皮样细胞衬里的ICTs中退化的生精小管有关。研究结果表明，这些病变构成支持细胞的化生变化。
