Boorman G A, Banas D A, Eustis S L, Haseman J K
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Toxicol Pathol. 1987;15(4):451-6. doi: 10.1177/019262338701500410.
Pancreatic tissue from untreated and corn oil gavage control rats in four chronic (2-year) toxicity and carcinogenicity studies was examined microscopically for the presence of acinar hyperplasia, acinar adenoma, and acinar carcinoma. Formalin-fixed pancreatic tissue that had been saved from these rats was then examined for grossly visible lesions; and all additional available pancreatic tissue was embedded, routinely processed, and sectioned at 5-7 microns for histopathological examination. There were no additional gross lesions identified in the review of the residual tissues. However, microscopic examination of this additional tissue resulted in a marked increase in the number of proliferative lesions diagnosed. The incidence of acinar cell adenomas increased from 1/188 (0.5%) to 28/193 (15%) in untreated control male rats and from 8/194 (4%) to 73/195 (37%) in corn oil gavage vehicle control male rats. There were similar increases in hyperplasia in vehicle and untreated male rats, and similar but much less dramatic increases in hyperplasia and adenoma in vehicle and untreated control female rats. The previously reported effect of increased proliferative lesions of the exocrine pancreas of male rats given corn oil vehicle was confirmed. In addition, examination of a larger tissue sample identified a similar but smaller effect of the corn oil vehicle in female F344 rats that had not been detected by routine sampling of the pancreas.
在四项慢性（2年）毒性和致癌性研究中，对未经处理的大鼠以及接受玉米油灌胃的对照大鼠的胰腺组织进行了显微镜检查，以确定是否存在腺泡增生、腺泡腺瘤和腺泡癌。然后，对从这些大鼠保存下来的福尔马林固定胰腺组织进行大体可见病变检查；将所有额外可得的胰腺组织进行包埋、常规处理，并切成5 - 7微米厚的切片进行组织病理学检查。在对残留组织的复查中未发现其他大体病变。然而，对这些额外组织的显微镜检查导致诊断出的增殖性病变数量显著增加。在未经处理的雄性对照大鼠中，腺泡细胞腺瘤的发生率从1/188（0.5%）增至28/193（15%），在接受玉米油灌胃的雄性对照大鼠中，从8/194（4%）增至73/195（37%）。在灌胃组和未经处理的雄性大鼠中增生情况有类似增加，在灌胃组和未经处理的雌性对照大鼠中增生和腺瘤也有类似但程度小得多的增加。此前报道的给予玉米油载体的雄性大鼠外分泌胰腺增殖性病变增加的效应得到了证实。此外，对更大组织样本的检查发现，玉米油载体对雌性F344大鼠有类似但较小的效应，这在胰腺常规取样时未被检测到。
