Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Alagappa University, Karaikudi, India.
Department of Botany, Alagappa University, Karaikudi, India.
Chem Biol Drug Des. 2022 Jan;99(1):103-110. doi: 10.1111/cbdd.13932. Epub 2021 Aug 22.
In recent years, biological macromolecules have piqued the interest of researchers owing to their vast variety of biological uses. As a result, the marine sponge is a multicellular heterotrophic parazoan with chemicals for defence against predator assaults, biofouling and microbial diseases. These priceless molecules are known as secondary metabolites, and they are essential for survival in a highly competitive environment. So far, over 5,000 marine natural compounds have been extracted from marine sponges, making them an excellent option for drug formulation. One among them is, aaptamine, a marine alkaloid with a benzo[de][1,6]-napthyridine framework extensively distributed in marine sponges. Due to this reason, aaptamine has been intensively researched for various biological purposes, including cancer and protease inhibition, offering fresh insights into novel treatments. Keeping this in mind, we reviewed the biological significance of the marine sponge alkaloid aaptamine.
近年来，由于其在生物方面的广泛应用，生物大分子引起了研究人员的兴趣。因此，海绵是一种多细胞异养后生动物，具有防御捕食者攻击、生物污损和微生物疾病的化学物质。这些宝贵的分子被称为次生代谢物，它们是在高度竞争的环境中生存的关键。到目前为止，已经从海绵中提取了超过 5000 种海洋天然化合物，这使它们成为药物制剂的绝佳选择。其中之一是 aaptamine，一种具有苯并[de][1,6]-萘啶骨架的海洋生物碱，广泛分布在海绵中。由于这个原因，aaptamine 已经被广泛研究用于各种生物目的，包括癌症和蛋白酶抑制，为新的治疗方法提供了新的见解。考虑到这一点，我们回顾了海洋海绵生物碱 aaptamine 的生物学意义。
