Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics (INCT-Nanobiofar), Federal University of Minas Gerais, Belo Horizonte, Brazil.
Department of Physiology and Biophysics, Proteomics Group (NPF), Federal University of Minas Gerais, Belo Horizonte, Brazil.
Adv Exp Med Biol. 2024;1443:103-128. doi: 10.1007/978-3-031-50624-6_6.
Anxiety and depression are two of the most common mental disorders worldwide, with a lifetime prevalence of up to 30%. These disorders are complex and have a variety of overlapping factors, including genetic, environmental, and behavioral factors. Current pharmacological treatments for anxiety and depression are not perfect. Many patients do not respond to treatment, and those who do often experience side effects. Animal models are crucial for understanding the complex pathophysiology of both disorders. These models have been used to identify potential targets for new treatments, and they have also been used to study the effects of environmental factors on these disorders. Recent proteomic methods and technologies are providing new insights into the molecular mechanisms of anxiety disorder and depression. These methods have been used to identify proteins that are altered in these disorders, and they have also been used to study the effects of pharmacological treatments on protein expression. Together, behavioral and proteomic research will help elucidate the factors involved in anxiety disorder and depression. This knowledge will improve preventive strategies and lead to the development of novel treatments.
焦虑症和抑郁症是全球最常见的两种精神障碍，终身患病率高达 30%。这些疾病非常复杂，有多种重叠的因素，包括遗传、环境和行为因素。目前焦虑症和抑郁症的药物治疗并不完美。许多患者对治疗没有反应，而那些有反应的患者经常会出现副作用。动物模型对于理解这两种疾病的复杂病理生理学至关重要。这些模型已被用于确定新治疗方法的潜在靶点，也被用于研究环境因素对这些疾病的影响。最近的蛋白质组学方法和技术为焦虑症和抑郁症的分子机制提供了新的见解。这些方法已被用于鉴定这些疾病中改变的蛋白质，也被用于研究药物治疗对蛋白质表达的影响。行为和蛋白质组学研究将共同阐明焦虑症和抑郁症涉及的因素。这些知识将改善预防策略，并导致新的治疗方法的开发。
