Currie D C, Pavia D, Agnew J E, Lopez-Vidriero M T, Diamond P D, Cole P J, Clarke S W
Department of Thoracic Medicine, Brompton Hospital, London.
Thorax. 1987 Feb;42(2):126-30. doi: 10.1136/thx.42.2.126.
Tracheobronchial clearance was measured by a radioaerosol technique in 12 patients with bronchiectasis, seven patients with chronic obstructive lung disease expectorating mucoid sputum daily (group X), eight patients with chronic obstructive lung disease but negligible sputum expectoration (group Y), and 10 healthy subjects. The patients with bronchiectasis all expectorated purulent sputum daily (mean wet weight 47 g/day), had reduced forced expiratory volume in one second (FEV1) (mean 47.5% predicted), and were unable to avoid coughing during the six hour observation period. None of the patients with bronchiectasis or the healthy subjects were current smokers. There were five current smokers in group X and six in group Y. The mean FEV1 in group X was 41% predicted and in group Y 52% predicted, both values similar to that of the patients with bronchiectasis. Tracheobronchial clearance in the first six hours after inhalation of radioaerosol was significantly (p less than 0.01) slower in patients with bronchiectasis than in matched healthy subjects despite more proximal deposition of radioaerosol (p = 0.01) and more coughing (p less than 0.01) in the former. Tracheobronchial clearance in patients with bronchiectasis was impaired to a similar degree to that in patients with chronic obstructive lung disease but no bronchiectasis.
采用放射性气溶胶技术对12例支气管扩张症患者、7例每日咳出黏液样痰的慢性阻塞性肺疾病患者（X组）、8例慢性阻塞性肺疾病但咳痰极少的患者（Y组）和10名健康受试者进行气管支气管清除功能测定。支气管扩张症患者均每日咳出脓性痰（平均湿重47克/天），一秒用力呼气容积（FEV1）降低（平均为预测值的47.5%），且在6小时观察期内无法避免咳嗽。支气管扩张症患者和健康受试者均无当前吸烟者。X组有5名当前吸烟者，Y组有6名。X组的平均FEV1为预测值的41%，Y组为52%，这两个值与支气管扩张症患者相似。尽管支气管扩张症患者放射性气溶胶近端沉积更多（p = 0.01）且咳嗽更多（p < 0.01），但吸入放射性气溶胶后前6小时的气管支气管清除功能仍显著（p < 0.01）慢于匹配的健康受试者。支气管扩张症患者的气管支气管清除功能受损程度与无支气管扩张的慢性阻塞性肺疾病患者相似。
