Fortiphyte Inc., Berkeley CA, United States.
Department of Biology, University of Washington, Seattle WA, United States.
Curr Opin Plant Biol. 2021 Aug;62:102089. doi: 10.1016/j.pbi.2021.102089. Epub 2021 Jul 29.
Plants are resistant to most pathogens because of an immune system that perceives invading microbes and activates defense. A large repertoire of innate immune receptors mediates specific direct or indirect recognition of pathogen-derived molecules. Disease is often a consequence of insufficient immune surveillance, and the transfer of immune receptor genes from resistant plants to susceptible crop varieties is an effective strategy for combating disease outbreaks. We discuss approaches for identifying intracellular and cell surface immune receptors, with particular focus on recently developed and emerging methodologies. We also review considerations for the transfer of immune receptor genes into crop species, including additional host factors that may be required for immune receptor function. Together, these concepts lay out a broadly applicable playbook for developing crop varieties with durable disease resistance.
植物对大多数病原体具有抗性，因为它们具有感知入侵微生物并激活防御的免疫系统。大量先天免疫受体介导对病原体衍生分子的特异性直接或间接识别。疾病通常是免疫监视不足的结果，将免疫受体基因从抗性植物转移到易感作物品种是应对疾病爆发的有效策略。我们讨论了鉴定细胞内和细胞表面免疫受体的方法，特别关注最近开发和新兴的方法。我们还回顾了将免疫受体基因转移到作物物种中的考虑因素，包括可能对免疫受体功能有要求的其他宿主因素。这些概念共同为开发具有持久抗病性的作物品种制定了一个广泛适用的方案。
