贝伐珠单抗给药对低氧诱导性肺动脉高压大鼠模型的影响。
Effects of bevacizumab administration on the hypoxia - induced pulmonary hypertension rat model.
机构信息
Department of Occupational Diseases, Occupational and Environmental Diseases Hospital, Ankara, Turkey.
Department of Medical Microbiology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
出版信息
Turk J Med Sci. 2021 Oct;51(5):2752-2762. doi: 10.3906/sag-2101-76. Epub 2021 Oct 21.
BACKGROUND
Bevacizumab is a chemotherapeutic drug, which selectively binds to vascular endothelial growth factor (VEGF) and mainly inhibits angiogenesis and neovascularization. We aimed to study the possible effects of bevacizumab on right ventricular pressure (RVP), right ventricular hypertrophy, and VEGF, in hypoxia - induced pulmonary hypertension (PH) rat model.
METHODS
24 adult Wistar Albino rats were randomly divided into four groups: control group - saline; Bevacizumab Group; PH Group; PH + Bevacizumab Group. In hypoxia - induced model, 10% oxygen and 90% nitrogen were applied in a plexiglas box for eight days to PH Group and PH + Bevacizumab Group. On day eight, RVPs were measured directly from the heart, and then animals were sacrificed. Heart and lung tissues were examined, and Fulton index was measured.
RESULTS
RVP, Fulton index, and tissue VEGF scores were significantly lower in PH + Bevacizumab group than PH group: median (ranges), RVP, mmHg, 37.8 (33.0-39.0) and 32.3 (28.0-35.0), p: 0.01; Fulton index: 0.30 (0.29-0.33) and 0.25 (0.24-0.26), p: 0.003; tissue VEGF scores: 5.1 (4.8-5.3) and 4.0 (3.8 4.1), p: 0.004, respectively.
DISCUSSION
Bevacizumab, which is indeed an antineoplastic agent, might have a favorable effect on hypoxia - induced pulmonary hypertension.
背景
贝伐珠单抗是一种化疗药物，它选择性地与血管内皮生长因子（VEGF）结合，主要抑制血管生成和新血管形成。我们旨在研究贝伐珠单抗对缺氧诱导的肺动脉高压（PH）大鼠模型中右心室压力（RVP）、右心室肥厚和 VEGF 的可能影响。
方法
24 只成年 Wistar 白化大鼠随机分为四组：对照组-生理盐水；贝伐珠单抗组；PH 组；PH+贝伐珠单抗组。在缺氧诱导模型中，将 10%氧气和 90%氮气应用于有机玻璃箱中 8 天，使 PH 组和 PH+贝伐珠单抗组产生 PH。在第 8 天，直接从心脏测量 RVPs，然后处死动物。检查心脏和肺组织，并测量富尔顿指数。
结果
PH+贝伐珠单抗组的 RVP、富尔顿指数和组织 VEGF 评分均明显低于 PH 组：中位数（范围），RVP，mmHg，37.8（33.0-39.0）和 32.3（28.0-35.0），p：0.01；富尔顿指数：0.30（0.29-0.33）和 0.25（0.24-0.26），p：0.003；组织 VEGF 评分：5.1（4.8-5.3）和 4.0（3.8-4.1），p：0.004。
讨论
贝伐珠单抗，实际上是一种抗肿瘤药物，可能对缺氧诱导的肺动脉高压有有益的影响。
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