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东亚裔甲状腺眼病患者下睑退缩合并睑内翻的矫正

Correction of lower eyelid retraction combined with entropion in thyroid eye disease patients of East Asian ancestry.

作者信息

Ma Yue, Tang Meiting, Kikkawa Don O, Lu Wei

机构信息

Ophthalmology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.

Shiley Eye Institute, San Diego, CA, USA.

出版信息

Eur J Ophthalmol. 2022 Jul;32(4):2475-2480. doi: 10.1177/11206721211035613. Epub 2021 Jul 31.

Abstract

PURPOSE

This study evaluates causes and treatment of lower eyelid retraction with co-existing entropion in Thyroid Eye Disease (TED) patients of East Asian ancestry.

METHODS

The medical records for 25 eyelids from 15 TED patients with lower eyelid retraction and entropion who had undergone combined orbital decompression and lower eyelid retraction correction surgery at the Second Hospital of Dalian Medical University from January 2017 to December 2018 were prospectively reviewed. We build a numerical model of biomechanics to analyze von Mises stress and displacement at the lower eyelid.

RESULTS

The mean follow-up duration was 6 ± 2 months. The difference of mean exophthalmos was 5.16 ± 1.21 mm ( = 21.26,  = 4.479E-17 < 0.05). The difference of mean MRD2 was 1.9 ± 0.14 mm ( = 67.57,  = 6.751E-29 < 0.05). About 2 of 25 eyelids entropion recurred postoperatively; the overall success rate was 92%. The biomechanical analysis results reveal that the eyelid margin is given more stress and caused more displacement in East Asian ancestry under the same force of pressure.

CONCLUSIONS

This study shows that the lower eyelid retraction with coexistent entropion is attributable to the unique anatomical features of patients of East Asians ancestry. We corrected the lower eyelid retraction and entropion during the orbital decompression operation. The results show that this method is safe and effective. It can simultaneously improve the symptoms of TED patients such as exophthalmos, lower eyelid retraction, and entropion, with minimal complications.

摘要

目的

本研究评估东亚血统甲状腺眼病(TED)患者下睑退缩合并睑内翻的病因及治疗方法。

方法

对2017年1月至2018年12月在大连医科大学附属第二医院接受眼眶减压联合下睑退缩矫正手术的15例患有下睑退缩和睑内翻的TED患者的25只眼睑的病历进行前瞻性回顾。我们建立了一个生物力学数值模型来分析下睑的冯·米塞斯应力和位移。

结果

平均随访时间为6±2个月。平均眼球突出度差异为5.16±1.21mm(=21.26,=4.479E-17<0.05)。平均MRD2差异为1.9±0.14mm(=67.57,=6.751E-29<0.05)。25只眼睑中有2只术后睑内翻复发;总体成功率为92%。生物力学分析结果显示,在相同压力作用下,东亚血统人群的眼睑边缘受到的应力更大,位移也更大。

结论

本研究表明,下睑退缩合并睑内翻归因于东亚血统患者的独特解剖特征。我们在眼眶减压手术中矫正了下睑退缩和睑内翻。结果表明该方法安全有效。它可以同时改善TED患者的眼球突出、下睑退缩和睑内翻等症状,并发症最少。

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