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甲状腺相关眼病中同期眼眶减压与上睑退缩矫正术与分期手术的比较

Simultaneous orbital decompression and correction of upper eyelid retraction versus staged procedures in thyroid-related orbitopathy.

作者信息

Ben Simon Guy J, Mansury Ahmad M, Schwarcz Robert M, Lee Seongmu, McCann John D, Goldberg Robert A

机构信息

Division of Orbital and Ophthalmic Plastic Surgery, Jules Stein Eye Institute, and Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

出版信息

Ophthalmology. 2005 May;112(5):923-32. doi: 10.1016/j.ophtha.2004.12.028.

Abstract

PURPOSE

To evaluate the outcome of eyelid retraction surgery in thyroid-related orbitopathy (TRO) patients in 2 different surgical settings: done simultaneously with orbital decompression or as a staged procedure after orbital decompression.

DESIGN

Retrospective, comparative, nonrandomized clinical study.

PARTICIPANTS

Ninety-six patients (158 eyes).

METHODS

A review of electronic medical records of TRO patients who underwent surgery for upper eyelid retraction and orbital decompression at the Jules Stein Eye Institute in 1999 to 2003 was performed. Data regarding eyelid position, comprehensive eye examination, surgical outcome, and complications were analyzed.

MAIN OUTCOME MEASURES

Anatomical and functional success based on margin reflex distance (MRD1; < or = 5 mm was graded as mild retraction; > 5 mm and < 7 mm, moderate; and > 7 mm, severe), and patients' discomfort.

RESULTS

One hundred fifty-eight eyelid retraction surgeries were performed on 96 TRO patients (18 male and 78 female; mean age, 48 years); mean follow up time was 15 (+/-12) months. Group 1 consisted of patients undergoing simultaneous eyelid retraction surgery and orbital decompression and comprised 97 cases (surgeries). Group 2 included 61 cases of staged surgery: orbital decompression and eyelid retraction at a later stage. The groups had similar surgical outcomes, and > 85% had a better eyelid position postoperatively. Reoperation rates for residual or recurrent eyelid retraction were similar, overcorrection was higher in group 2 (5% vs. 0%, P = 0.03). Changes in MRD1, lagophthalmos, and exophthalmos were similar (P > 0.05, independent samples t test). Correction of eyelid retraction was effective in treating patients' discomfort and exposure keratopathy (P = 0.04, chi2). No severe complications occurred after orbital decompression or eyelid retraction surgery in this group of patients.

CONCLUSIONS

Transconjunctival Muller's muscle recession for correction of eyelid retraction in mild to moderate TRO patients, performed simultaneously with deep lateral wall orbital decompression, resulted in acceptable eyelid position in two thirds of our patients. Overcorrection and consecutive ptosis occurred less often after combined orbital decompression and eyelid retraction surgery than after isolated eyelid repositioning surgery. If confirmed in prospective controlled studies, eyelid-repositioning surgery performed at the time of orbital decompression may decrease the number of total procedures and compress the time needed for surgical rehabilitation.

摘要

目的

评估在两种不同手术情况下甲状腺相关眼病(TRO)患者眼睑退缩手术的效果:与眼眶减压同时进行或在眼眶减压后分期进行。

设计

回顾性、对比性、非随机临床研究。

参与者

96例患者(158只眼)。

方法

对1999年至2003年在朱尔斯·斯坦眼科研究所接受上睑退缩和眼眶减压手术的TRO患者的电子病历进行回顾。分析有关眼睑位置、全面眼部检查、手术效果和并发症的数据。

主要观察指标

根据边缘反射距离(MRD1;≤5mm为轻度退缩;>5mm且<7mm为中度;>7mm为重度)以及患者不适情况评估解剖学和功能上的成功。

结果

对96例TRO患者(18例男性和78例女性;平均年龄48岁)进行了158次眼睑退缩手术;平均随访时间为15(±12)个月。第1组由同时进行眼睑退缩手术和眼眶减压的患者组成,包括97例(手术)。第2组包括61例分期手术:先进行眼眶减压,后期进行眼睑退缩。两组手术效果相似,超过85%的患者术后眼睑位置改善。残余或复发性眼睑退缩的再次手术率相似,第2组的过度矫正发生率较高(5%对0%,P = 0.03)。MRD1、兔眼和眼球突出的变化相似(P>0.05,独立样本t检验)。眼睑退缩的矫正有效缓解了患者的不适和暴露性角膜病变(P = 0.04,卡方检验)。该组患者在眼眶减压或眼睑退缩手术后未发生严重并发症。

结论

对于轻度至中度TRO患者,经结膜米勒肌后退矫正眼睑退缩并同时进行眶外侧壁深层减压,三分之二的患者术后眼睑位置可接受。与单纯眼睑复位手术相比,眼眶减压联合眼睑退缩手术后过度矫正和继发性上睑下垂的发生率较低。如果在前瞻性对照研究中得到证实,在眼眶减压时进行眼睑复位手术可能会减少总手术次数并缩短手术康复所需时间。

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