氯取代 6H-二苯并[b,d]吡喃-6-酮天然产物、Graphislactone G 以及 Palmariols A 和 B 的合成。
Synthesis of Chloro-Substituted 6H-Dibenzo[b,d]pyran-6-one Natural Products, Graphislactone G, and Palmariols A and B.
机构信息
Faculty of Engineering, University of Toyama.
Graduate School of Innovative Life Science, University of Toyama.
出版信息
Chem Pharm Bull (Tokyo). 2021;69(8):781-788. doi: 10.1248/cpb.c21-00316.
A palladium-mediated intramolecular aryl-aryl coupling reaction was applied to the total synthesis of the bioactive natural products, graphislactone G (1), and palmariols A (2) and B (3), which possess an unusual chloro-subsutituent on the 6H-dibenzo[b,d]pyran-6-one skeleton. Based on the transition state model of the coupling reaction, the mechanistic aspect for the regioselectivity of the aryl-aryl coupling reaction is also discussed.
钯介导的分子内芳基-芳基偶联反应被应用于生物活性天然产物graphislactone G（1）、palmariols A（2）和 B（3）的全合成，它们在 6H-二苯并[b，d]吡喃-6-酮骨架上具有不寻常的氯取代基。基于偶联反应的过渡态模型，还讨论了芳基-芳基偶联反应的区域选择性的反应机理。
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