过去 20 年美国肾细胞癌发病率和死亡率的趋势：基于 SEER 的研究。
Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study.
机构信息
Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Faculty of Medicine, Ain Shams University, Cairo, Egypt; Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH.
出版信息
Clin Genitourin Cancer. 2019 Feb;17(1):46-57.e5. doi: 10.1016/j.clgc.2018.10.002. Epub 2018 Oct 11.
BACKGROUND
Renal-cell carcinoma (RCC) is one of the common malignancies in the United States. RCC incidence and mortality have been changing for many reasons. We performed a thorough investigation of incidence and mortality trends of RCC in the United States using the cell Surveillance, Epidemiology, and End Results (SEER) database.
PATIENTS AND METHODS
The 13 SEER registries were accessed for RCC cases diagnosed between 1992 and 2015. Incidence and mortality were calculated by demographic and tumor characteristics. We calculated annual percentage changes of these rates. Rates were expressed as 100,000 person-years.
RESULTS
A total of 104,584 RCC cases were reviewed, with 47,561 deaths. The overall incidence was 11.281 per 100,000 person-years. Incidence increased by 2.421% per year (95% confidence interval, 2.096, 2.747; P < .001) but later became stable since 2008. However, the incidence of clear-cell subtype continued to increase (1.449%; 95% confidence interval, 0.216, 2.697; P = .024). RCC overall mortality rates have been declining since 2001. However, mortality associated with distant RCC only started to decrease in 2012, with an annual percentage change of 18.270% (95% confidence interval, -28.775, -6.215; P = .006).
CONCLUSION
Despite an overall increase in the incidence of RCC, there has been a recent plateau in RCC incidence rates with a significant decrease in mortality.
背景
肾细胞癌（RCC）是美国常见的恶性肿瘤之一。由于多种原因，RCC 的发病率和死亡率一直在发生变化。我们使用细胞监测、流行病学和最终结果（SEER）数据库对美国 RCC 的发病率和死亡率趋势进行了全面调查。
患者和方法
访问了 1992 年至 2015 年间诊断的 13 个 SEER 登记处的 RCC 病例。根据人口统计学和肿瘤特征计算发病率和死亡率。我们计算了这些比率的年变化百分比。比率表示为每 10 万人年。
结果
共回顾了 104584 例 RCC 病例，其中 47561 例死亡。总体发病率为每 100000 人年 11.281 例。发病率每年增加 2.421%（95%置信区间，2.096，2.747；P<.001），但自 2008 年以来趋于稳定。然而，透明细胞亚型的发病率继续增加（1.449%；95%置信区间，0.216，2.697；P=.024）。自 2001 年以来，RCC 的总死亡率一直在下降。然而，只有在 2012 年，远处 RCC 相关的死亡率才开始下降，年变化百分比为 18.270%（95%置信区间，-28.775，-6.215；P=.006）。
结论
尽管 RCC 的发病率总体上有所增加，但最近 RCC 的发病率已趋于平稳，死亡率显著下降。
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