State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Front Immunol. 2021 Jul 14;12:693579. doi: 10.3389/fimmu.2021.693579. eCollection 2021.
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a newly emerging, highly transmitted and pathogenic coronavirus that has caused global public health events and economic crises. As of March 4, 2021, more than 100 million people have been infected, more than 2 million deaths have been reported worldwide, and the numbers are continuing to rise. To date, a specific drug for this lethal virus has not been developed to date, and very little is currently known about the immune evasion mechanisms of SARS-CoV-2. The aim of this review was to summarize and sort dozens of published studies on PubMed to explore the pathogenic features of SARS-CoV-2, as well as the possible immune escape mechanisms of this virus.
严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）是一种新出现的、高传播性和致病性冠状病毒，已引发全球公共卫生事件和经济危机。截至 2021 年 3 月 4 日，已有超过 1 亿人感染，全球报告超过 200 万人死亡，且数字还在继续上升。迄今为止，尚未针对这种致命病毒开发出特定药物，目前对 SARS-CoV-2 的免疫逃逸机制知之甚少。本综述的目的是总结和整理几十篇发表在 PubMed 上的研究，以探讨 SARS-CoV-2 的发病特征，以及该病毒可能的免疫逃逸机制。
