Ying Li, Wang Deli, Du Guankui
Key Laboratory of Molecular Biology, Hainan Medical University, Haikou, China.
Haikou Customs, District P. R. China, Haikou, China.
Evid Based Complement Alternat Med. 2021 Jul 9;2021:5592518. doi: 10.1155/2021/5592518. eCollection 2021.
() fruit has long been used in traditional Chinese medicine. In our study, the bioactive components of its roots, fruit, and leaves were investigated, and their potential medical value was predicted. The root, fruit, and leaf samples were analyzed using a UPLC-MS/MS system. The mass spectrometry outcomes were annotated by MULTIAQUANT. The "compound-disease targets" were used to construct a pharmacology network. A total of 293, 277, and 251 components were identified in the roots, fruit, and leaves, respectively. The fruit of had a higher abundance of flavonols. The roots of were enriched in flavonols and phenolic acids. The leaves of exhibited high contents of flavonols, phenolic acids, and tannins. Furthermore, network pharmacology analysis showed that flavonoids are the most important effectors in the fruit of and phenolic acids are the most important effectors in the roots and leaves. Moreover, the results suggested that the tissues of might play a role in the regulation of disease-related genes. The whole plant of is rich in natural drug components, and each tissue has high medicinal value. Therefore, comprehensive utilization of can greatly improve its economic value.
()果实长期以来一直应用于传统中药。在我们的研究中,对其根、果实和叶的生物活性成分进行了研究,并预测了它们的潜在医学价值。使用超高效液相色谱-串联质谱系统(UPLC-MS/MS)对根、果实和叶样本进行分析。质谱分析结果由MULTIAQUANT进行注释。利用“化合物-疾病靶点”构建药理学网络。在根、果实和叶中分别鉴定出293、277和251种成分。()的果实中黄酮醇含量较高。()的根富含黄酮醇和酚酸。()的叶中黄酮醇、酚酸和单宁含量较高。此外,网络药理学分析表明,黄酮类化合物是()果实中最重要的效应物,酚酸是根和叶中最重要的效应物。而且,结果表明()的组织可能在疾病相关基因的调控中发挥作用。()全株富含天然药物成分,各组织具有较高的药用价值。因此,对()进行综合利用可大大提高其经济价值。