School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin 150040, China.
Molecules. 2024 Aug 18;29(16):3905. doi: 10.3390/molecules29163905.
fructus (AOF), the dried mature fruit of Miquel of the Zingiberaceae family, shows many special pharmacological effects. In recent years, there has been an abundance of research results on AOF. In this paper, the new compounds isolated from AOF since 2018 are reviewed, including terpenes, flavonoids, diarylheptanoids, phenolic acid, sterols, alkanes, fats, etc. The isolation methods that were applied include the microwave-assisted method, response surface method, chiral high-performance liquid chromatography-multiple reaction monitoring-mass spectrometry (HPLC-MRM-MS) analytical method, ultra-high-performance liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry (UPLC-Orbitrap-HRMS) method, ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method, hot water leaching method, ethanol leaching method, and so on. Additionally, the pharmacological effects of AOF found from 2018 to 2024 are also summarized, including neuroprotection, regulation of metabolic disorders, antioxidant activity, antiapoptosis, antiinflammatory activity, antidiabetic activity, antihyperuricemia, antiaging, antidiuresis, immune regulation, anti-tumor activity, renal protection, hepatoprotection, and anti-asthma. This paper provides a reference for further research on AOF.
莪术（AOF），姜科莪术属植物的干燥成熟果实，具有多种特殊的药理作用。近年来，对 AOF 的研究成果颇丰。本文综述了 2018 年以来从 AOF 中分离得到的新化合物，包括萜类、黄酮类、二芳基庚烷类、酚酸类、甾体、烷烃、脂肪等。应用的分离方法包括微波辅助法、响应面法、手性高效液相色谱-多重反应监测-质谱（HPLC-MRM-MS）分析方法、超高效液相色谱-四极杆-静电场轨道阱高分辨质谱（UPLC-Orbitrap-HRMS）法、超高效液相色谱-串联质谱（UPLC-MS/MS）法、热水浸提法、乙醇浸提法等。此外，还总结了 2018 年至 2024 年 AOF 的药理作用，包括神经保护、代谢紊乱调节、抗氧化活性、抗细胞凋亡、抗炎活性、抗糖尿病活性、抗高尿酸血症、抗衰老、利尿、免疫调节、抗肿瘤活性、肾保护、肝保护和抗哮喘。本文为进一步研究 AOF 提供了参考。
