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摩洛哥(L.)帕尔氏鳞茎水提取物和有机提取物的矿物质含量、化学分析、抗糖尿病和抗氧化活性以及抗菌能力

Mineral Content, Chemical Analysis, Antidiabetic and Antioxidant Activities, and Antibacterial Power of Aqueous and Organic Extracts of Moroccan (L.) Parl. Bulbs.

作者信息

Boulfia Mohamed, Lamchouri Fatima, Senhaji Souad, Lachkar Nacima, Bouabid Khadija, Toufik Hamid

机构信息

Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health & Quality of Life (SNAMOPEQ), Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez, B.P. 1223 Taza-Gare, Taza, Morocco.

出版信息

Evid Based Complement Alternat Med. 2021 Jul 20;2021:9932291. doi: 10.1155/2021/9932291. eCollection 2021.

Abstract

Medicinal plants are a rich source of bioactive phytochemicals or bionutrients. Studies carried out during the past few decades have shown that these phytochemicals play an important role in preventing metabolic diseases such as cancer and diabetes. The present study was dedicated to the analysis of mineral and chemical composition and evaluation of antidiabetic, antioxidant, and antibacterial properties of aqueous and organic extracts of , a plant with a long history of therapeutic and food use. Mineral content was determined using inductively coupled plasma atomic emission spectroscopy. Chemical composition was carried out by extraction of essential oils, preparation of aqueous and organic extracts, and qualitative and quantitative analysis. The biological study consisted of the evaluation of antidiabetic activity by inhibition of three enzymes, antioxidant activity by five tests, and antibacterial activity by the disc diffusion method. The correlation between chemical composition and antidiabetic and antioxidant properties was explored by PCA. The results showed that contains high levels of Fe, K, P, Na, Cu, Mg, and Ca with values, respectively, in the order of 33552, 1843.14, 756.36, 439.65, 303.9, 272.37, and 20.55 mg/kg. Quantitative analysis showed that the diethyl ether extract had the highest content of polyphenols (129.75 ± 0.29 g GAE/mg E), flavonoids (988.26 ± 0.18 g QE/mg E), and tannins (30.22 ± 0.15 g CE/mg E). All extracts of possess inhibitory activity of alpha-amylase, alpha-glucosidase, and beta-galactosidase enzymes, mainly the decocted and the acetone extract. The antioxidant results showed that organic extracts are more active than aqueous extracts especially diethyl ether extract which was similarly found to have an antibacterial effect on and PCA allowed us to deduce that phenolic compounds, flavonoids, and tannins are strongly correlated with antioxidant and antidiabetic activity. may have potential remedy in the prevention of metabolic disease.

摘要

药用植物是生物活性植物化学物质或生物营养素的丰富来源。过去几十年进行的研究表明,这些植物化学物质在预防癌症和糖尿病等代谢性疾病中发挥着重要作用。本研究致力于分析一种具有悠久治疗和食用历史的植物的矿物质和化学成分,并评估其水提取物和有机提取物的抗糖尿病、抗氧化和抗菌特性。使用电感耦合等离子体原子发射光谱法测定矿物质含量。通过提取精油、制备水提取物和有机提取物以及定性和定量分析来进行化学成分分析。生物学研究包括通过抑制三种酶评估抗糖尿病活性、通过五项测试评估抗氧化活性以及通过纸片扩散法评估抗菌活性。通过主成分分析探索化学成分与抗糖尿病和抗氧化特性之间的相关性。结果表明,该植物含有高水平的铁、钾、磷、钠、铜、镁和钙,含量分别为33552、1843.14、756.36、439.65、303.9、272.37和20.55毫克/千克。定量分析表明,二乙醚提取物的多酚(129.75±0.29克没食子酸当量/毫克提取物)、黄酮类化合物(988.26±0.18克槲皮素当量/毫克提取物)和单宁(30.22±0.15克儿茶素当量/毫克提取物)含量最高。该植物的所有提取物都具有抑制α-淀粉酶、α-葡萄糖苷酶和β-半乳糖苷酶的活性,主要是水煎剂和丙酮提取物。抗氧化结果表明,有机提取物比水提取物更具活性,尤其是二乙醚提取物,同样发现其对[具体菌种1]和[具体菌种2]有抗菌作用。主成分分析使我们推断,酚类化合物、黄酮类化合物和单宁与抗氧化和抗糖尿病活性密切相关。该植物在预防代谢性疾病方面可能具有潜在的治疗作用。

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