Sharifi-Rad Javad, Bahukhandi Amit, Dhyani Praveen, Sati Priyanka, Capanoglu Esra, Docea Anca Oana, Al-Harrasi Ahmed, Dey Abhijit, Calina Daniela
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
G.B Pant National Institute of Himalayan Environment, Almora, India.
Front Nutr. 2021 Jul 16;8:664197. doi: 10.3389/fnut.2021.664197. eCollection 2021.
Neoechinulins are diketopiperazine type indole alkaloids that demonstrate radical scavenging, anti-inflammatory, antiviral, anti-neurodegenerative, neurotrophic factor-like, anticancer, pro-apoptotic, and anti-apoptotic properties. An array of neoechinulins such as neoechinulins A-E, isoechinulins A-C, cryptoechunilin have been isolated from various fungal sources like sp., sp., etc. Besides, neoechinulin derivatives or stereoisomers were also obtained from diverse non-fungal sources , and so on. The main purpose of this review is to provide update information on neoechinulins and their analogues about the molecular mechanisms of the pharmacological action and possible future research. The recent data from this review can be used to create a basis for the discovery of new neoechinulin-based drugs and their analogues in the near future. The online databases PubMed, Science and Google scholar were researched for the selection and collection of data from the available literature on neoechinulins, their natural sources and their pharmacological properties. The published books on this topic were also analysed. and assays have established the potential of neoechinulin A as a promising anticancer and anti-neuroinflammatory lead molecule. Neoechinulin B was also identified as a potential antiviral drug against hepatitis C virus. Toxicological and clinical trials are needed in the future to improve the phyto-pharmacological profile of neoquinolines. From the analysis of the literature, we found that neoechinulins and their derivatives have special biological potential. Although some modern pharmacological analyzes have highlighted the molecular mechanisms of action and some signalling pathways, the correlation between these phytoconstituents and pharmacological activities must be validated in the future by preclinical toxicological and clinical studies.
新刺孢菌素是二酮哌嗪型吲哚生物碱，具有自由基清除、抗炎、抗病毒、抗神经退行性变、神经营养因子样、抗癌、促凋亡和抗凋亡特性。一系列新刺孢菌素，如新刺孢菌素A - E、异新刺孢菌素A - C、隐新刺孢菌素，已从各种真菌来源如 属、 属等中分离出来。此外，新刺孢菌素衍生物或立体异构体也从不同的非真菌来源获得，等等。本综述的主要目的是提供关于新刺孢菌素及其类似物药理作用分子机制和未来可能研究的最新信息。本综述的最新数据可用于在不久的将来为发现基于新刺孢菌素的新药及其类似物奠定基础。对在线数据库PubMed、Science和谷歌学术进行了检索，以从有关新刺孢菌素、其天然来源及其药理特性的现有文献中选择和收集数据。还分析了关于该主题的已出版书籍。 和 分析已证实新刺孢菌素A作为一种有前景的抗癌和抗神经炎症先导分子的潜力。新刺孢菌素B也被确定为一种潜在的抗丙型肝炎病毒药物。未来需要进行毒理学和临床试验，以改善新喹啉类化合物的植物药理学特征。通过对文献的分析，我们发现新刺孢菌素及其衍生物具有特殊的生物学潜力。尽管一些现代药理分析突出了作用的分子机制和一些信号通路，但这些植物成分与药理活性之间的相关性未来必须通过临床前毒理学和临床研究来验证。
