用于癌症光疗的纳米级金属有机框架
Nanoscale Metal-Organic Frameworks for Phototherapy of Cancer.
作者信息
Lan Guangxu, Ni Kaiyuan, Lin Wenbin
机构信息
Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States.
出版信息
Coord Chem Rev. 2019 Jan 15;379:65-81. doi: 10.1016/j.ccr.2017.09.007. Epub 2017 Oct 21.
Abstract
Phototherapy involves the irradiation of tissues with light, and is commonly implemented in the forms of photodynamic therapy (PDT) and photothermal therapy (PTT). Photosensitizers (PSs) are often needed to improve the efficacy and selectivity of phototherapy enhanced singlet oxygen generation in PDT and photothermal responses in PTT. In both cases, efficient and selective delivery of PSs to the diseased tissues is of paramount importance. Nanoscale metal-organic frameworks (nMOFs), a new class of hybrid materials built from metal connecting points and bridging ligands, have been examined as nanocarriers for drug delivery due to their compositional and structural tunability, highly porous structures, and good biocompatibility. This review summarizes recent advances on using nMOFs as nanoparticle PSs for applications in PDT and PTT.
摘要
光疗是指用光照射组织，通常以光动力疗法（PDT）和光热疗法（PTT）的形式实施。光疗通常需要光敏剂（PSs）来提高疗效和选择性，增强PDT中的单线态氧生成以及PTT中的光热响应。在这两种情况下，将PSs高效且选择性地递送至病变组织至关重要。纳米级金属有机框架（nMOFs）是一类由金属连接点和桥连配体构建而成的新型杂化材料，由于其组成和结构的可调性、高度多孔的结构以及良好的生物相容性，已被研究用作药物递送的纳米载体。本综述总结了将nMOFs用作纳米颗粒PSs在PDT和PTT应用中的最新进展。
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