Division of Colorectal and Anal Surgery, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.
Guangxi Clinical Research Center for Colorectal Cancer, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211037418. doi: 10.1177/15330338211037418.
Systemic inflammation and nutritional status have been shown to be associated with the prognosis of colorectal cancer. The purpose of this study was to evaluate the impact of the serum C-reactive protein-to-body mass index ratio on the prognosis of patients with curatively resected colorectal cancer.
We conducted a retrospective analysis of a database of 2,471 eligible patients with colorectal cancer who underwent curative resection at our hospital between 2004 and 2019. The optimal cut-off for CPR-to-BMI ratio was determined using maximally selected rank statistics. Patients were divided into 2 groups according to the cut-off value of the serum C-reactive protein-to-body mass index ratio. Kaplan-Meier curves and Cox regression analysis were used to compare overall survival. A two-sided -value < 0.05 was considered statistically significant.
The proportion of patients with a high C-reactive protein-to-body mass index ratio increased with increasing age, male sex, right-sided colon cancer, poorly differentiated tumors, advanced-stage disease, local/distant metastases, tumor-node-metastasis stage, and microsatellite instability. In subgroup analysis according to tumor-node-metastasis stage, the overall survival of the high C-reactive protein-to-body mass index ratio group was significantly shorter than that of the low C-reactive protein-to-body mass index ratio group ( < 0.001). Multivariate analysis identified age, differentiation, tumor-node-metastasis stage, carcinoembryonic antigen level, and the C-reactive protein-to-body mass index ratio as independent poor prognostic factors for overall survival.
The C-reactive protein-to-body mass index ratio predicts the prognosis of patients with curatively resected colorectal cancer and is an independent risk factor for overall survival in patients with colorectal cancer.
系统炎症和营养状况与结直肠癌的预后相关。本研究旨在评估血清 C 反应蛋白与体重指数比值对接受根治性切除术的结直肠癌患者预后的影响。
我们对 2004 年至 2019 年期间在我院接受根治性切除术的 2471 例符合条件的结直肠癌患者的数据库进行了回顾性分析。使用最大选择秩统计确定 C 反应蛋白与体重指数比值的最佳截断值。根据血清 C 反应蛋白与体重指数比值的截断值将患者分为 2 组。使用 Kaplan-Meier 曲线和 Cox 回归分析比较总生存率。双侧 P 值 < 0.05 被认为具有统计学意义。
具有高 C 反应蛋白与体重指数比值的患者比例随着年龄的增长、男性、右半结肠癌、分化程度差、晚期疾病、局部/远处转移、肿瘤-淋巴结-转移分期和微卫星不稳定性的增加而增加。根据肿瘤-淋巴结-转移分期进行亚组分析，高 C 反应蛋白与体重指数比值组的总生存率明显短于低 C 反应蛋白与体重指数比值组（<0.001）。多因素分析确定年龄、分化、肿瘤-淋巴结-转移分期、癌胚抗原水平和 C 反应蛋白与体重指数比值是总生存率的独立预后不良因素。
C 反应蛋白与体重指数比值可预测接受根治性切除术的结直肠癌患者的预后，是结直肠癌患者总生存率的独立危险因素。
