Centre for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, United Kingdom.
Infect Immun. 2021 Oct 15;89(11):e0037421. doi: 10.1128/IAI.00374-21. Epub 2021 Aug 2.
The Streptococcus pneumoniae capsule is essential for disease pathogenesis, suggesting that even minor genetic changes within the locus could potentially have important consequences. Arends et al. (D. W. Arends, W. R. Miellet, J. D. Langereis, T. H. A. Ederveen, et al., Infect Immun 89:e00246-21, 2021, https://doi.org/10.1128/IAI.00246-21) have identified 79 different nonsynonymous single-nucleotide polymorphisms (SNPs) in the locus of 338 19A serotype strains and shown significant variations between strains in nucleotide sugar content and capsule shedding. Further work is required to characterize whether any of these changes have important functional consequences on capsule-host interactions.
肺炎链球菌荚膜对于疾病发病机制至关重要，这表明 基因座内的微小遗传变化都可能具有重要的后果。Arends 等人（D. W. Arends、W. R. Miellet、J. D. Langereis、T. H. A. Ederveen 等人，Infect Immun 89:e00246-21, 2021, https://doi.org/10.1128/IAI.00246-21）已经在 338 株 19A 血清型菌株的 基因座中鉴定出 79 种不同的非同义单核苷酸多态性（SNP），并表明菌株之间在核苷酸糖含量和荚膜脱落方面存在显著差异。需要进一步的工作来表征这些变化中是否有任何对荚膜-宿主相互作用具有重要的功能后果。
