Kachalova L M, Popova N S
Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Sep-Oct;37(5):897-905.
In dogs, the influence of chronic administration of the agonist (L-DOPA) and antagonist (haloperidol) of central dopamine processes on functional interrelations of the brain structures was studied by dynamics of evoked potentials. Cortical-subcortical relations during formation of a motor habit are described in intact animals: basic functional regimes of central integration are singled out--sensory and motor one. Change of their equilibrium is the general principle of systemic reconstructions elicited by differently directed interferences in dopamine processes. Against the background of chronic administration of haloperidol, a sensory-motor imbalance is formed due to uniform functioning of the basal ganglia as analyzer of the signal stimulus; simultaneously the utilization of afferentation elicited by the movement is limited. A variant is revealed of intercentral relations corresponding to bradykinesia development. Under chronic administration of L-DOPA, interrelations of sensory and motor regimes become competitive; basal ganglia are provided with nontypical kinds of afferentations. Intercentral relations variant is examined corresponding to development of psycho-motor excitation. The results are discussed in connection with pathogenic and compensatory mechanisms of some symptoms of parkinsonism and schizophrenia.
在犬类中，通过诱发电位动力学研究了中枢多巴胺过程的激动剂（左旋多巴）和拮抗剂（氟哌啶醇）的长期给药对脑结构功能相互关系的影响。完整动物描述了运动习惯形成过程中的皮质-皮质下关系：区分出中枢整合的基本功能模式——感觉和运动模式。它们平衡的改变是多巴胺过程中不同方向干扰引发的系统重构的一般原则。在长期给予氟哌啶醇的背景下，由于基底神经节作为信号刺激分析器的统一功能，形成了感觉-运动失衡；同时，运动引发的传入信息的利用受到限制。揭示了一种与运动迟缓发展相对应的中枢间关系变体。在长期给予左旋多巴的情况下，感觉和运动模式的相互关系变得具有竞争性；基底神经节具有非典型的传入类型。研究了与精神运动性兴奋发展相对应的中枢间关系变体。结合帕金森病和精神分裂症某些症状的致病和代偿机制对结果进行了讨论。
