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皮层和新纹状体的多巴胺反应系统在情境性条件反射组织中的作用。

Role of dopaminoreactive systems of the cortex and the neostriatum in the organization of situational conditioned reflexes.

作者信息

Voilokova N L

机构信息

Laboratory of Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg.

出版信息

Neurosci Behav Physiol. 1995 Jan-Feb;25(1):86-91. doi: 10.1007/BF02359255.

DOI:10.1007/BF02359255
PMID:7777152
Abstract

The results of experiments on dogs with dysfunction of the dopaminoreactive system of the brain suggest the nonidenticality of its different divisions (cortical, striatal, mesencephalic) in the organization of situational conditioned reflexes. It was demonstrated that the nigrostriatal system is involved to a greater degree in the spatial analysis of signals, while the mesocortical system is more involved in the analysis of their biological significance. The dopaminoreactive system of the caudate nucleus is associated to a greater degree with the realization of cognitive, while that of the putamen is associated with the realization of motor programs of situational conditioned reflexes. The thesis of the necessity of the coordinated functioning of the DA-reactive systems for the organization of goal-directed behavior is substantiated.

摘要

对大脑多巴胺反应系统功能失调的狗进行的实验结果表明,其不同部分(皮质、纹状体、中脑)在情境性条件反射的组织中具有非同一性。结果表明,黑质纹状体系统在信号的空间分析中参与程度更高,而中脑皮质系统则更多地参与对其生物学意义的分析。尾状核的多巴胺反应系统在更大程度上与认知的实现相关,而壳核的多巴胺反应系统则与情境性条件反射的运动程序的实现相关。多巴胺反应系统协同运作对于组织目标导向行为的必要性这一论点得到了证实。

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本文引用的文献

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[The localization of corticosteroid receptors in the dopaminergic structures of the canine brain].[犬脑多巴胺能结构中皮质类固醇受体的定位]
Fiziol Zh Im I M Sechenova. 1993 Jan;79(1):33-7.
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Functions of the prefrontal cortex. Behavioral investigations using ablation and electrophysiological techniques in rats, cats, dogs, and monkeys.前额叶皮质的功能。在大鼠、猫、狗和猴子身上使用切除和电生理技术进行的行为学研究。
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[作用于犬多巴胺系统时脑结构功能相互关系的重组原则]
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Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.多巴胺的相位性释放与紧张性释放以及多巴胺系统反应性的调节:关于精神分裂症病因的一种假说
Neuroscience. 1991;41(1):1-24. doi: 10.1016/0306-4522(91)90196-u.