Isin Zh M, Suleĭmenov B M, Aĭkimbaev A M
Zh Mikrobiol Epidemiol Immunobiol. 1987 Nov(11):84-8.
The work deals with the results obtained in the study of the activity of the cytocidal systems of phagocytes in great gerbils under normal conditions and during the plague infectious process. The data have been analyzed in comparison with the corresponding characteristics of phagocytic activity in mice. Changes in the oxygen-dependent metabolism (ODM) of neutrophils and macrophages, responsible for the functioning of their oxygen-dependent cytocidal systems, in plague show features characteristic of the nonspecific systemic postaggression reaction (SPAR). In Y. pestis-sensitive animals (mice), changes in the ODM activity of phagocytes are manifested as shock of different severity. In great gerbils, these changes present as true SPAR. The degree of the sensitivity of animals to Y. pestis infection is mainly determined by the initial level of the activity of oxygen-sensitive cytocidal systems of neutrophils (determined in the nitro blue tetrazolium spontaneous reduction test). In great gerbils this level exceeds the corresponding characteristics in mice 2.6- to 8.7-fold.
该研究探讨了在正常条件下及鼠疫感染过程中，大沙鼠吞噬细胞杀细胞系统活性的研究结果。已将这些数据与小鼠吞噬活性的相应特征进行了比较分析。鼠疫中，负责其氧依赖性杀细胞系统功能的中性粒细胞和巨噬细胞的氧依赖性代谢（ODM）变化呈现出非特异性全身性攻击后反应（SPAR）的特征。在对鼠疫耶尔森菌敏感的动物（小鼠）中，吞噬细胞ODM活性的变化表现为不同严重程度的休克。在大沙鼠中，这些变化呈现为真正的SPAR。动物对鼠疫耶尔森菌感染的敏感程度主要取决于中性粒细胞氧敏感杀细胞系统活性的初始水平（通过硝基蓝四氮唑自发还原试验测定）。在大沙鼠中，该水平超过小鼠相应特征的2.6至8.7倍。
