Department of Gynecological Oncology, The First Hospital of Jilin University, Changchun, Jilin, China.
Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin, China.
J Int Med Res. 2021 Aug;49(8):3000605211027783. doi: 10.1177/03000605211027783.
Retiform hemangioendothelioma (RH) is a rare borderline-malignant vascular tumor with specific histological characteristics, usually occurring in the limbs and trunk. We report the case of a 63-year-old woman who presented with a painless, oval nodule that had been growing slowly on her left vulva for 3 years. Magnetic resonance imaging of the pelvic cavity revealed a 4.4- × 2.7- × 1.8-cm cystic lesion in the subcutaneous fat of the left vulva. Resection beyond the macroscopic border was performed. Pathology revealed vascular structures with elongated and narrow arborizing vascular channels that were arranged in a retiform pattern resembling rete testis tissue. Immunohistochemical endothelial staining was positive for CD31, CD34, and Friend leukemia integration-1 (FLI-1). The above features confirmed a diagnosis of RH. There was no local recurrence or metastasis during the 26-month follow-up. RH of the vulva is rare, and its diagnosis is supported by specific histological characteristics and immunohistochemical staining for CD31, CD34, and FLI-1. Wide surgical resection with tumor-free margins is important for a favorable prognosis.
网状血管内皮细胞瘤（RH）是一种罕见的具有特定组织学特征的交界性恶性血管肿瘤，通常发生在四肢和躯干。我们报告了一例 63 岁女性患者的病例，她因左外阴无痛性椭圆形结节缓慢生长 3 年就诊。盆腔磁共振成像显示左外阴皮下脂肪中有一个 4.4×2.7×1.8cm 的囊性病变。行超过肉眼边界的切除。病理显示血管结构具有细长且狭窄的树枝状血管通道，呈网状模式排列，类似于睾丸网组织。免疫组织化学内皮染色 CD31、CD34 和 Friend 白血病整合-1（FLI-1）阳性。上述特征证实了 RH 的诊断。在 26 个月的随访中，无局部复发或转移。外阴 RH 罕见，其诊断依据是特定的组织学特征和 CD31、CD34 和 FLI-1 的免疫组织化学染色。广泛的手术切除并保证肿瘤无残留是良好预后的关键。
