Wong Shi-Bing, Wang Yi-Mei, Lin Chih-Chun, Geng Scott Kun, Vanegas-Arroyave Nora, Pullman Seth L, Kuo Sheng-Han, Pan Ming-Kai
Department of Pediatrics, Taipei Tzu Chi General Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, 23142, Taiwan.
School of Medicine, Tzu Chi University, Hualien, 97071, Taiwan.
Cerebellum. 2022 Jun;21(3):425-431. doi: 10.1007/s12311-021-01309-9. Epub 2021 Aug 3.
Enhanced cerebellar oscillations have recently been identified in essential tremor (ET) patients as a key pathophysiological change. Since ET is considered a heterogeneous group of diseases, we investigated whether cerebellar oscillations differ in ET subtypes (familial vs. sporadic). This study aims to determine cerebellar physiology in familial and sporadic ET. Using surface electroencephalogram, we studied cerebellar physiology in 40 ET cases (n = 22 familial and n = 18 sporadic) and 20 age-matched controls. Both familial and sporadic ET cases had an increase in the intensity of cerebellar oscillations when compared to controls. Interestingly, cerebellar oscillations correlated with tremor severity in familial ET but not in sporadic ET. Our study demonstrated that ET cases have enhanced cerebellar oscillations, and the different relationships between cerebellar oscillations and tremor severity in familial and sporadic ET suggest diverse cerebellar pathophysiology.
近期研究发现，特发性震颤（ET）患者小脑振荡增强是关键的病理生理变化。由于ET被认为是一组异质性疾病，我们研究了小脑振荡在ET亚型（家族性与散发性）中是否存在差异。本研究旨在确定家族性和散发性ET的小脑生理学特征。我们使用表面脑电图，对40例ET患者（n = 22例家族性和n = 18例散发性）和20例年龄匹配的对照者进行了小脑生理学研究。与对照组相比，家族性和散发性ET患者的小脑振荡强度均增加。有趣的是，小脑振荡与家族性ET的震颤严重程度相关，而与散发性ET无关。我们的研究表明，ET患者存在小脑振荡增强，家族性和散发性ET中小脑振荡与震颤严重程度之间的不同关系提示了不同的小脑病理生理学机制。
