City of Hope Comprehensive Cancer Center, Department of medical oncology and developmental therapeutics, Duarte, CA United States.
City of Hope Comprehensive Cancer Center, Department of medical oncology and developmental therapeutics, Duarte, CA United States.
Clin Genitourin Cancer. 2022 Feb;20(1):92-92.e6. doi: 10.1016/j.clgc.2021.07.008. Epub 2021 Jul 10.
Prostate cancer is the most commonly diagnosed cancer in American men, with striking differences between ethnic groups. Given the potential for lifestyle or genetic variations between subsets of Asian-American men to impact prostate cancer behavior, we sought to define the outcomes after radical prostatectomy among various Asian groups treated at an NCI-designated comprehensive cancer center.
The City of Hope IRB-approved prostatectomy database was searched from 2003 to 2015 to identify Asian-American men. Clinical and pathologic features were collected and analyzed for association with biochemical recurrence-free survival and overall survival (OS). Categorical data were evaluated using χand Fisher's exact tests. Survival curves were compared between groups using log-rank testing.
Three hundred and eighty-three Asian-American men were included in the dataset. While Asian men as a group had lower BMI than African-American and white men in the database, there was a wide range between ethnic sub-groups. Chinese men more commonly presented with D'Amico low risk disease features (P= .04) compared to other Asian men. Pacific Islander men had the lowest rate of ≥T3 stage and the highest biochemical recurrence-free survival. OS for Chinese men was better than for all Asian patients combined (P= .046). After controlling for D'Amico risk and in multivariate analysis, Chinese men still had improved OS than other Asian men after prostatectomy (P= .03).
Asian-American men have differing prostate cancer characteristics. Future efforts to delineate and impact upon prostate cancer outcomes should categorize Asian men by subgroup in order to better elucidate biology, lifestyle factors and/or treatment preferences that may contribute to observed differences.
前列腺癌是美国男性最常见的癌症，不同种族之间存在显著差异。鉴于亚裔美国男性亚群之间的生活方式或遗传差异可能影响前列腺癌的行为，我们试图定义在 NCI 指定的综合癌症中心治疗的各种亚裔群体接受根治性前列腺切除术后的结果。
从 2003 年到 2015 年，搜索了希望之城 IRB 批准的前列腺切除术数据库，以确定亚裔美国男性。收集并分析了临床和病理特征，以与生化无复发生存和总生存（OS）相关联。使用 χ和 Fisher 确切检验评估分类数据。使用对数秩检验比较组间的生存曲线。
在数据集中共纳入了 383 名亚裔美国男性。虽然亚裔男性作为一个群体的 BMI 低于数据库中的非裔美国人和白人男性，但在种族亚群之间存在很大差异。与其他亚裔男性相比，中国男性更常见 D'Amico 低危疾病特征（P=.04）。太平洋岛民男性的≥T3 期比例最低，生化无复发生存率最高。与所有亚裔患者相比，中国男性的 OS 更好（P=.046）。在控制了 D'Amico 风险并进行多变量分析后，中国男性在前列腺切除术后的 OS 仍优于其他亚裔男性（P=.03）。
亚裔美国男性具有不同的前列腺癌特征。为了更好地阐明可能导致观察到的差异的生物学、生活方式因素和/或治疗偏好，未来应按亚组对亚裔男性进行分类，以努力描绘和影响前列腺癌的结果。
