Ishikawa E
Department of Urology, Kobe General Hospital.
Hinyokika Kiyo. 1987 Sep;33(9):1342-8.
To clarify the renal function induced by water deprivation-induced dehydration, intrarenal blood flow and changes in adenine nucleotide level in the renal tissue were investigated. Male SD rats were completely deprived of water for 2, 4 and 5 days. The intrarenal blood flow was determined by the hydrogen-gas clearance method and adenine nucleotide level in the renal tissue by high pressure liquid chromatography (HPLC) on the 2nd, 4th, and 5th day after water deprivation. The renal function and energy charge (EC = [ATP + 1/2 ADP]/[ATP + ADP + AMP]) were normal in all rats. In the dehydrated rats, the urine and blood were concentrated, and the medullary blood flow decreased. The mean arterial blood pressure was in the lower limit of renal perfusion pressure under autoregulation. In conclusion, the lower limit of renal perfusion pressure under autoregulation and urine and blood concentration due to water deprivation-induced dehydration may easily cause acute renal failure.
为阐明缺水诱导的脱水对肾功能的影响，研究了肾内血流及肾组织中腺嘌呤核苷酸水平的变化。雄性SD大鼠完全缺水2、4和5天。在缺水后的第2、4和5天，采用氢气清除法测定肾内血流，用高压液相色谱法（HPLC）测定肾组织中的腺嘌呤核苷酸水平。所有大鼠的肾功能和能荷（EC = [ATP + 1/2 ADP]/[ATP + ADP + AMP]）均正常。在脱水大鼠中，尿液和血液浓缩，髓质血流减少。平均动脉血压处于自动调节下肾灌注压的下限。总之，自动调节下肾灌注压的下限以及缺水诱导的脱水导致的尿液和血液浓缩可能易引发急性肾衰竭。
