Constantin Maria-Magdalena, Ciurduc Maria-Diana, Bucur Stefana, Olteanu Rodica, Ionescu Razvan Adrian, Constantin Traian, Furtunescu Florentina
Third Department, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Second Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Exp Ther Med. 2021 Sep;22(3):981. doi: 10.3892/etm.2021.10413. Epub 2021 Jul 12.
Psoriasis is a chronic, immune-mediated inflammatory disease of unknown etiology that may be associated with abnormal T-lymphocyte function. Ocular manifestations associated with psoriasis, particularly artropathic or pustular psoriasis, usually affect men, often during exacerbations of the disease. It has been reported that eye damage tends to occur later compared with cutaneous or joint manifestations, blindness being the most disabling complication. Previous studies have focused on ophthalmic manifestations and identified several etiopathogenic mechanisms. Psoriasis may be associated with eye complications such as lesions of the eyelids, conjunctiva and others, with systemic inflammation being the main contributor. In addition, the treatment used for psoriasis may cause ocular changes. The main ophthalmic manifestations associated with psoriasis are keratoconjunctivitis sicca, blepharitis, conjunctivitis and uveitis. The treatment of uveitis, perceived as one of the most serious eye conditions, is controversial and has yet to be clearly determined. Thus, the aim of the present review was to emphasize the importance of regular eye examination for patients with psoriasis, either those receiving biological treatment or those not receiving treatment, in order to diagnose and manage the disease appropriately.
银屑病是一种病因不明的慢性、免疫介导的炎症性疾病，可能与T淋巴细胞功能异常有关。与银屑病相关的眼部表现，尤其是关节病型或脓疱型银屑病，通常在疾病加重期影响男性。据报道，与皮肤或关节表现相比，眼部损害往往出现较晚，失明是最致残的并发症。以往的研究主要集中在眼部表现，并确定了几种发病机制。银屑病可能与眼部并发症有关，如眼睑、结膜等部位的病变，全身炎症是主要原因。此外，用于治疗银屑病的药物可能会引起眼部变化。与银屑病相关的主要眼部表现为干眼症、睑缘炎、结膜炎和葡萄膜炎。葡萄膜炎被认为是最严重的眼部疾病之一，其治疗存在争议，尚未明确确定。因此，本综述的目的是强调定期对银屑病患者进行眼部检查的重要性，无论患者是否接受生物治疗，以便对疾病进行适当的诊断和管理。
