Guangdong Provincial Key Laboratory of Marine Biotechnology, Department of Biology, College of Science, Shantou University, Shantou 515063, Guangdong, China.
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China.
Food Funct. 2021 Sep 20;12(18):8635-8646. doi: 10.1039/d1fo01201k.
Ulcerative colitis (UC) is a chronic lifetime disorder with a high incidence worldwide. A functional food-based method to prevent UC would be a good option for disease control. oligosaccharides (GLOs) should have potent benefits for the gastrointestinal tract, based on fermentation assessed in our previous study. This study evaluated the therapeutic potential of GLOs in UC, as well as their possible mechanisms of action. The administration of GLOs was able to reduce the severity of dextran sulphate sodium-induced colitis by protecting mice from weight loss, reductions in colon length, inflammatory infiltration, and colon damage. Gut microbiota composition analysis showed that at the phylum level, GLOs could restore the composition of Bacteroidetes and decrease the level of Firmicutes. Consistently, it increased the contents of beneficial microbial metabolites and short-chain fatty acids in the mouse colitis model. In conclusion, GLOs could comprise a promising functional food strategy to alleviate UC symptoms.
溃疡性结肠炎（UC）是一种全球范围内发病率较高的终身性疾病。基于我们之前的研究结果，基于功能性食品的方法来预防 UC 将是一种很好的疾病控制选择。基于之前的研究结果，低聚果糖（GLOs）应该对胃肠道有很强的益处。本研究评估了 GLOs 在 UC 中的治疗潜力及其可能的作用机制。GLOs 的给药能够通过保护小鼠免受体重减轻、结肠长度缩短、炎症浸润和结肠损伤，从而减轻葡聚糖硫酸钠诱导的结肠炎的严重程度。肠道微生物群组成分析表明，在门水平上，GLOs 可以恢复拟杆菌门的组成，并降低厚壁菌门的水平。一致地，它增加了结肠炎模型中有益微生物代谢物和短链脂肪酸的含量。总之，GLOs 可以成为一种有前途的功能性食品策略，以缓解 UC 症状。
