Lu Si-Yuan, Liu Yang, Tang Shijie, Zhang Wancong, Yu Qiuyong, Shi Changqi, Cheong Kit-Leong
Guangdong Provincial Key Laboratory of Marine Biotechnology, Department of Biology, College of Science, Shantou University, Shantou 515063, Guangdong, China.
Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China.
Food Chem X. 2021 Dec 22;13:100197. doi: 10.1016/j.fochx.2021.100197. eCollection 2022 Mar 30.
polysaccharide (GLP) has varieties of antioxidation, however, the therapeutic effects of GLP on ulcerative colitis (UC) and the potential mechanisms involved are still incomplete. In the study, the analysis of the ζ-potential, thermal, and morphology properties demonstrated that GLP was a negatively charged polymer, and had great thermostability and irregular network. Moreover, the GLP treatment has the effects of reducing the severity of colitis caused by dextran sulfate sodium by alleviating the colon damage of mice, and increasing the amount of short-chain fatty acids in the intestines, alleviating histopathological inflammation. The sequencing results and α-diversity analysis showed that GLP could improve biodiversity, restore the abundance of Bacteroidetes, and decrease the proportion of Firmicutes. The level of CCL-25 and CCR-9 were inhibited, CD40 and TGF-β1 were increased. In summary, GLP has potentiality to be utilized as a hopeful functional food to the UC patients.
多糖（GLP）具有多种抗氧化作用，然而，GLP对溃疡性结肠炎（UC）的治疗效果及其潜在机制仍不完整。在该研究中，对ζ电位、热性能和形态特性的分析表明，GLP是一种带负电荷的聚合物，具有很高的热稳定性和不规则网络结构。此外，GLP治疗具有减轻葡聚糖硫酸钠所致结肠炎严重程度的作用，通过减轻小鼠结肠损伤、增加肠道短链脂肪酸含量以及减轻组织病理学炎症来实现。测序结果和α多样性分析表明，GLP可改善生物多样性，恢复拟杆菌属的丰度，并降低厚壁菌门的比例。CCL-25和CCR-9水平受到抑制，CD40和TGF-β1水平升高。综上所述，GLP有潜力作为一种有前景的功能性食品应用于UC患者。
