School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-Power Nuclear Technology Collaborative Innovation Center, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, China.
Molecules. 2021 Oct 31;26(21):6604. doi: 10.3390/molecules26216604.
Naringin is a kind of multi-source food additive which has been explored broadly for its various biological activities and therapeutic potential. In the present study, the protective effect and mechanism of naringin on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice were investigated. The results showed that naringin significantly alleviated DSS-induced colitis symptoms, including disease activity index (DAI), colon length shortening, and colon pathological damage. The tissue and serum secretion of inflammatory cytokines, as well as the oxidative stress, were decreased accordingly upon naringin intervention. Naringin also decreased the proteins involved in inflammation and increased the expression of tight junction (TJ) proteins. Moreover, naringin increased the relative abundance of / and reduced the content of to improve the intestinal flora disorder caused by DSS, which promotes the intestinal health of mice. It was concluded that naringin can significantly ameliorate the pathogenic symptoms of UC through inhibiting inflammatory response and regulating intestinal microbiota, which might be a promising natural therapeutic agent for the dietary treatment of UC and the improvement of intestinal symbiosis.
柚皮苷是一种多生源的食品添加剂，因其具有多种生物活性和治疗潜力而被广泛研究。本研究旨在探讨柚皮苷对葡聚糖硫酸钠（DSS）诱导的溃疡性结肠炎（UC）模型小鼠的保护作用及机制。结果表明，柚皮苷能显著缓解 DSS 诱导的结肠炎症状，包括疾病活动指数（DAI）、结肠缩短和结肠病理损伤。柚皮苷干预后，组织和血清中炎症因子的分泌以及氧化应激水平均降低。柚皮苷还降低了参与炎症反应的蛋白水平，增加了紧密连接（TJ）蛋白的表达。此外，柚皮苷增加了/的相对丰度，降低了 的含量，改善了 DSS 引起的肠道菌群失调，从而促进了小鼠的肠道健康。综上所述，柚皮苷通过抑制炎症反应和调节肠道微生物群，显著改善 UC 的发病症状，可能是一种有前途的天然治疗剂，可用于 UC 的饮食治疗和改善肠道共生。
