American Cancer Society, Atlanta, Georgia.
Emory University, Atlanta, Georgia.
Cancer Epidemiol Biomarkers Prev. 2021 Oct;30(10):1956-1964. doi: 10.1158/1055-9965.EPI-20-1810. Epub 2021 Aug 4.
Cannabis use is increasing, including among smokers, an at-risk population for cancer. Research is equivocal on whether using cannabis inhibits quitting cigarettes. The current longitudinal study investigated associations between smoking cannabis and subsequently quitting cigarettes.
Participants were 4,535 adult cigarette smokers from a cohort enrolled in the American Cancer Society's Cancer Prevention Study-3 in 2009-2013. Cigarette quitting was assessed on a follow-up survey in 2015-2017, an average of 3.1 years later. Rates of quitting cigarettes at follow-up were examined by retrospectively assessed baseline cannabis smoking status (), and by frequency of cannabis smoking among recent cannabis smokers (: ≤3 days/month; : 4-19 days/month; : ≥20 days/month). Logistic regression models adjusted for sociodemographic factors, smoking- and health-related behaviors, and time between baseline and follow-up.
Adjusted cigarette quitting rates at follow-up did not differ significantly by baseline cannabis smoking status [never 36.2%, 95% confidence interval (CI), 34.5-37.8; former 34.1%, CI, 31.4-37.0; recent 33.6%, CI, 30.1-37.3], nor by frequency of cannabis smoking (low 31.4%, CI, 25.6-37.3; moderate 36.7%, CI, 30.7-42.3; high 34.4%, CI, 28.3-40.2) among recent baseline cannabis smokers. In cross-sectional analyses conducted at follow-up, the proportion of cigarette smokers intending to quit smoking cigarettes in the next 30 days did not differ by cannabis smoking status ( = 0.83).
Results do not support the hypothesis that cannabis smoking inhibits quitting cigarette smoking among adults.
Future longitudinal research should include follow-ups of >1 year, and assess effects of intensity/frequency of cannabis use and motivation to quit on smoking cessation.
大麻的使用正在增加，包括在吸烟人群中，而吸烟人群是癌症的高危人群。研究对于大麻的使用是否会抑制戒烟存在争议。目前这项纵向研究调查了吸烟大麻与随后戒烟之间的关联。
参与者是 2009-2013 年期间参加美国癌症协会癌症预防研究-3 的 4535 名成年香烟吸烟者。在 2015-2017 年的后续调查中评估了戒烟情况，平均随访时间为 3.1 年。通过回顾性评估基线大麻吸烟状况（从未吸烟、以前吸烟、最近吸烟）和最近吸烟大麻者的大麻吸烟频率（≤3 天/月、4-19 天/月、≥20 天/月）来检查随访时的戒烟率。使用逻辑回归模型调整了社会人口因素、吸烟和健康相关行为以及基线和随访之间的时间。
根据基线大麻吸烟状况，调整后的随访时的香烟戒烟率没有显著差异[从不吸烟 36.2%，95%置信区间（CI）为 34.5-37.8；以前吸烟 34.1%，CI 为 31.4-37.0；最近吸烟 33.6%，CI 为 30.1-37.3]，也与最近基线大麻吸烟者的大麻吸烟频率无关（低频率 31.4%，CI 为 25.6-37.3；中频率 36.7%，CI 为 30.7-42.3；高频率 34.4%，CI 为 28.3-40.2）。在随访时进行的横断面分析中，打算在未来 30 天内戒烟的香烟吸烟者比例与大麻吸烟状况没有差异（ = 0.83）。
结果不支持大麻吸烟抑制成年人戒烟的假设。
未来的纵向研究应包括随访时间超过 1 年，并评估大麻使用强度/频率和戒烟动机对戒烟的影响。
