Hoene Georg, Gruber Rudolf M, Leonhard Johanna J, Wiechens Bernhard, Schminke Boris, Kauffmann Philipp, Schliephake Henning, Brockmeyer Phillipp
Department of Oral and Maxillofacial Surgery, University Medical Center Goettingen, Goettingen D-37575, Germany.
Department of Orthodontics, University Medical Center Goettingen, Goettingen D-37575, Germany.
Mol Clin Oncol. 2021 Sep;15(3):189. doi: 10.3892/mco.2021.2351. Epub 2021 Jul 15.
Oral cancer therapy is associated with a loss in health-related quality of life (HRQOL) and can also lead to post-traumatic growth (PTG). The current study analyzed the relationship between HRQOL, PTG and influencing clinical factors after treatment. The coherent clinical data of 15 patients were retrospectively analyzed over a 1-year study period. HRQOL and PTG were studied using the University of Washington Quality of Life Version 4 (UW-QOL v4) and Posttraumatic Growth Inventory (PTGI) questionnaires. The results revealed that HRQOL was significantly decreased in a pre- to postoperative manner (P=0.011). Sex demonstrated a nearly significant effect on HRQOL (P=0.058). PTG was experienced the most after surgery, and continuously decreased over the 1-year study period. Patient age had a significant effect on PTG (P=0.040). A significant correlation was also established between HRQOL and PTG (P<0.05). HRQOL and PTG are important influencing factors during postoperative tumor follow-up care and should be simultaneously recorded to address individual patient needs and improve quality of treatment.
口腔癌治疗会导致健康相关生活质量（HRQOL）下降，也可能引发创伤后成长（PTG）。本研究分析了治疗后HRQOL、PTG与相关临床影响因素之间的关系。在为期1年的研究期间，对15例患者的连贯临床数据进行了回顾性分析。使用华盛顿大学生活质量量表第4版（UW-QOL v4）和创伤后成长量表（PTGI）问卷对HRQOL和PTG进行研究。结果显示，HRQOL在术前至术后显著下降（P = 0.011）。性别对HRQOL有近乎显著的影响（P = 0.058）。PTG在术后最为明显，并在1年的研究期间持续下降。患者年龄对PTG有显著影响（P = 0.040）。HRQOL与PTG之间也建立了显著相关性（P < 0.05）。HRQOL和PTG是术后肿瘤随访期间的重要影响因素，应同时记录以满足个体患者需求并提高治疗质量。
