Cheng Fajuan, Zheng Bin, Si Shubin, Wang Jianwei, Zhao Guiting, Yao Zhongshun, Niu Zhihong, He Wei
Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Department of Nephrology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Cell Dev Biol. 2021 Jul 19;9:666863. doi: 10.3389/fcell.2021.666863. eCollection 2021.
Bladder cancer (BCa) is the most prevalent malignancy of the urinary system. Circular RNAs (circRNAs), a novel subtype of non-coding RNAs, play a crucial role in physiological and developmental processes. CircRNAs mainly function as regulators of splicing process and transcription, microRNA sponges, and protein brackets. Recent advances in understanding the pathogenesis of BCa have led to the identification of an abundance of dysregulated circRNAs associated with BCa. These aberrantly expressed circRNAs eventually lead to abnormalities in biological, genetic, and epigenetic information. In this review, we introduce the potential of circRNAs as biomarkers for BCa diagnosis and prognosis. Notably, diverse mechanisms have been proposed for circRNAs driving carcinogenesis, including increasing cell proliferation, promoting invasive and migratory capacity, enhancing endothelial-mesenchymal transition, sustaining stemness, and enabling resistance to chemotherapy. Importantly, a full understanding of circRNA mechanisms is needed to mine promising therapeutic approaches for targeting BCa. In this paper, we present the latest advances in circRNAs and systemically summarize the characteristics and mechanisms of circRNAs in BCa, providing potential perspectives for BCa treatment.
膀胱癌（BCa）是泌尿系统中最常见的恶性肿瘤。环状RNA（circRNAs）是一种新型的非编码RNA亚型，在生理和发育过程中发挥着关键作用。CircRNAs主要作为剪接过程和转录的调节因子、微小RNA海绵和蛋白质支架发挥作用。近年来，在理解BCa发病机制方面取得的进展导致发现了大量与BCa相关的失调circRNAs。这些异常表达的circRNAs最终导致生物、遗传和表观遗传信息的异常。在本综述中，我们介绍了circRNAs作为BCa诊断和预后生物标志物的潜力。值得注意的是，已经提出了多种circRNAs驱动致癌作用的机制，包括增加细胞增殖、促进侵袭和迁移能力、增强内皮-间充质转化、维持干性以及产生化疗耐药性。重要的是，需要全面了解circRNA机制，以挖掘有前景的BCa靶向治疗方法。在本文中，我们介绍了circRNAs的最新进展，并系统总结了circRNAs在BCa中的特征和机制，为BCa治疗提供了潜在的观点。
