Yang Ruotong, Ma Liwei, Wan Junhu, Li Zhuofang, Yang Zhengwu, Zhao Zhuochen, Ming Liang
Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Key Clinical Laboratory of Henan Province, Zhengzhou, China.
Front Cell Dev Biol. 2023 Apr 20;11:1160381. doi: 10.3389/fcell.2023.1160381. eCollection 2023.
Ferroptosis is an emerging form of non-apoptotic regulated cell death which is different from cell death mechanisms such as autophagy, apoptosis and necrosis. It is characterized by iron-dependent lipid peroxide accumulation. Circular RNA (circRNA) is a newly studied evolutionarily conserved type of non-coding RNA with a covalent closed-loop structure. It exhibits universality, conservatism, stability and particularity. At present, the functions that have been studied and found include microRNA sponge, protein scaffold, transcription regulation, translation and production of peptides, etc. CircRNA can be used as a biomarker of tumors and is a hotspot in RNA biology research. Studies have shown that ferroptosis can participate in tumor regulation through the circRNA molecular pathway and then affect cancer progression, which may become a direction of cancer diagnosis and treatment in the future. This paper reviews the molecular biological mechanism of ferroptosis and the role of circular RNA in tumors and summarizes the circRNA related to ferroptosis in tumors, which may inspire research prospects for the precise prevention and treatment of cancer in the future.
铁死亡是一种新出现的非凋亡性程序性细胞死亡形式，不同于自噬、凋亡和坏死等细胞死亡机制。其特征是铁依赖性脂质过氧化物积累。环状RNA（circRNA）是一种新研究的具有进化保守性的非编码RNA，具有共价闭环结构。它具有普遍性、保守性、稳定性和特殊性。目前已研究发现的功能包括微小RNA海绵、蛋白质支架、转录调控、肽的翻译和产生等。CircRNA可作为肿瘤的生物标志物，是RNA生物学研究的热点。研究表明，铁死亡可通过circRNA分子途径参与肿瘤调控，进而影响癌症进展，这可能成为未来癌症诊断和治疗的一个方向。本文综述了铁死亡的分子生物学机制以及环状RNA在肿瘤中的作用，并总结了肿瘤中与铁死亡相关的circRNA，这可能为未来癌症的精准防治带来研究前景。
