Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, China.
Department of Chemical and Materials Engineering, Photo-sensitive Material Advanced Research and Technology Center (Photo-SMART), National Kaohsiung University of Science and Technology, Kaohsiung, China.
Methods Enzymol. 2021;657:181-222. doi: 10.1016/bs.mie.2021.06.033. Epub 2021 Jul 21.
In this chapter, we designed and synthesized a series of thiadiazoloquinoxaline (TQ)-based semiconducting polymers (SPs) with a broad absorption covering from NIR-I to NIR-II regions. Theoretical calculation suggests that the BTD-TQE with ester-substituted TQ-acceptor shows a large dihedral angle and narrow adiabatic energy as well as low radiative decay, resulting in higher reorganization energy for efficient photoinduced nonradiative decay (PNRD). As a result, the obtained BDT-TQE SP-cored nanoparticles, a NIR-II PA probe, exhibit a highest NIR-II photothermal conversion efficiency (61.6%) and achieved PA tracking of in situ hepatic tumor growth for 20 days. Herein, we propose a strategy to construct an effective NIR-II photoacoustic reagent through the enhanced PNRD effect of twisted intramolecular charge transfer (TICT), thereby extending the application of NIR-II PA reagents in in vivo bioimaging.
在本章中，我们设计并合成了一系列基于噻二唑并喹喔啉（TQ）的半导体聚合物（SP），其吸收范围从近红外一区扩展到近红外二区。理论计算表明，具有酯取代 TQ-受体的 BTD-TQE 具有较大的二面角和较窄的绝热能以及较低的辐射衰减，从而为有效的光诱导非辐射衰减（PNRD）提供了更高的重组能。因此，所获得的 BDT-TQE SP 核纳米粒子作为近红外二区光声探针，表现出最高的近红外二区光热转换效率（61.6%），并实现了原位肝肿瘤生长 20 天的光声跟踪。在此，我们提出了一种通过增强扭曲分子内电荷转移（TICT）的有效非辐射衰减来构建有效近红外二区光声试剂的策略，从而扩展了近红外二区光声试剂在体内生物成像中的应用。
