Flushing Meadows, New York.
Los Angeles, California.
Arthroscopy. 2021 Aug;37(8):2531-2532. doi: 10.1016/j.arthro.2021.05.056.
The use of biologic augmentation following microfracture for symptomatic cartilage defects of the knee with osseous involvement shows encouraging results. Bone marrow aspirate concentrate provides growth factors to the injury site, such as vascular endothelial growth factor, platelet-derived growth factor, transforming growth factor-βa, and bone morphogenetic proteins in addition to the mesenchymal stem cells present in the concentrate. Cellular-based therapies like mesenchymal stem cells are becoming more widely used in conjunction with surgical treatment of focal cartilage lesions with early promising results. Both treatment options improve clinical and radiographic outcomes. As for the efficacy of mesenchymal stem cells versus bone marrow aspirate concentrate, we believe that both have promising results.
在骨介入的膝关节有症状性软骨缺损的微骨折术后应用生物增强剂显示出令人鼓舞的结果。骨髓抽吸浓缩物向损伤部位提供生长因子，如血管内皮生长因子、血小板衍生生长因子、转化生长因子-βa 和骨形态发生蛋白，除了浓缩物中存在的间充质干细胞。细胞疗法，如间充质干细胞，与早期有希望的结果的局灶性软骨病变的手术治疗一起越来越广泛地应用。这两种治疗选择都改善了临床和影像学结果。至于间充质干细胞与骨髓抽吸浓缩物的疗效，我们认为两者都有很好的效果。
