Momò Fertilife Clinic, Bisceglie, Italy.
Eur Rev Med Pharmacol Sci. 2021 Aug;25(15):4964-4972. doi: 10.26355/eurrev_202108_26453.
Vitamin D (VitD) is a secosteroid hormone showing both antiproliferative and immunomodulatory effects. Its involvement in placental steroidogenesis and endometrial decidualization even plays a role in other gynecological functions, including assisted reproductive technology (ART). However, controversial data have been reported on its implication in pregnancy outcomes during In Vitro Fertilization (IVF) programs. In order to elucidate the VitD role in ART success, we evaluated serum and follicular fluid (FF) VitD levels in infertile women concerning the pregnancy rate.
In our IVF center, 446 patients, under the age of 42 years old, were evaluated in the period between January 2018 and December 2019. It is here important to clarify that, in order to respect the exclusion criteria, only 103 of them were enrolled for the study concerning the VitD evaluation in serum and follicular fluid at the time of the egg retrieval. This took place both in 34 pregnant patients (Group 1) and 69 non-pregnant ones (Group 2). Furthermore, the collection of these data gave us the opportunity to assess a possible correlation between the VitD levels and the achievement of pregnancy in the performed IVF cycles.
The studied group included 103 eligible women. The average age for Group 1 was 33.12 ± 3.72 yrs whereas 33.72+3.99 yrs (p=0.467) for Group 2. The main differences were observed concerning follicle numbers of 17-21 mm (p=0.0043), the number of retrieved oocytes (p=0.0207), as well as the number of mature oocytes (p=0.0233) among the different groups. Different reference ranges, established according to the pregnancy outcomes, revealed that pregnant women with >36 yrs showed significantly higher levels of VitD.
Increased serum and FF-VitD levels in women undergoing IVF with age ≥36 yrs, were significantly associated with a favorable outcome to achieve and carry on with the pregnancy.
维生素 D（VitD）是一种甾体激素，具有抗增殖和免疫调节作用。其在胎盘类固醇生成和子宫内膜蜕膜化中的作用甚至在其他妇科功能中发挥作用，包括辅助生殖技术（ART）。然而，关于其在体外受精（IVF）计划中对妊娠结局的影响，已有争议数据报道。为了阐明 VitD 在 ART 成功中的作用，我们评估了不孕妇女的血清和卵泡液（FF）VitD 水平与妊娠率的关系。
在我们的 IVF 中心，评估了 2018 年 1 月至 2019 年 12 月期间年龄在 42 岁以下的 446 名患者。在这里需要澄清的是，为了遵守排除标准，只有 103 名患者被纳入研究，以评估在取卵时血清和卵泡液中的 VitD 评估。这发生在 34 名怀孕患者（第 1 组）和 69 名未怀孕患者（第 2 组）中。此外，收集这些数据使我们有机会评估 VitD 水平与进行的 IVF 周期中妊娠的获得之间的可能相关性。
研究组包括 103 名符合条件的女性。第 1 组的平均年龄为 33.12±3.72 岁，第 2 组为 33.72±3.99 岁（p=0.467）。观察到的主要差异是 17-21 毫米卵泡数（p=0.0043）、取卵数（p=0.0207）以及不同组之间成熟卵数（p=0.0233）的差异。根据妊娠结局确定的不同参考范围表明，年龄≥36 岁接受 IVF 的孕妇 VitD 水平显著升高。
年龄≥36 岁接受 IVF 的女性血清和 FF-VitD 水平升高与获得和维持妊娠的良好结局显著相关。
