三种脑特异性蛋白基因中的ID序列。

ID sequences in the genes of three brain-specific proteins.

作者信息

Usui H, Kuwano R, Maeda T, Araki K, Sakimura K, Kushiya E, Takahashi Y

机构信息

Department of Neuropharmacology, Niigata University, Japan.

出版信息

Biochem Int. 1987 Oct;15(4):809-16.

PMID:3435544

Abstract

We characterized the brain-specific gene coding for rat S-100 protein beta-subunit and found three "brain identifier (ID)" elements, which have been proposed to regulate the gene expression in rat brain. The nucleotide sequences of these elements corresponded well with that of the consensus ID element and were clearly different from those of "ID-like" elements in rat beta B1-crystallin gene, etc. ID elements were also observed in the flanking regions of rat neuron-specific enolase and cholecystokinin genes, which were expressed in the neuronal cells. Direct repeats were observed in the regions flanking ID elements.

摘要

我们对编码大鼠S-100蛋白β亚基的脑特异性基因进行了表征，发现了三个“脑识别（ID）”元件，它们被认为可调节大鼠脑中的基因表达。这些元件的核苷酸序列与共有ID元件的序列高度吻合，且与大鼠βB1-晶状体蛋白基因等中的“类ID”元件序列明显不同。在大鼠神经元特异性烯醇化酶和胆囊收缩素基因的侧翼区域也观察到了ID元件，这些基因在神经元细胞中表达。在ID元件侧翼区域观察到了直接重复序列。