• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

目前有证据支持类黄酮在氧化应激相关皮肤病中的治疗潜力。

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses.

机构信息

Department of Anatomy, Southwest Medical University, Luzhou, People's Republic of China.

Department of Dermatology, Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.

出版信息

Redox Rep. 2021 Dec;26(1):134-146. doi: 10.1080/13510002.2021.1962094.

DOI:10.1080/13510002.2021.1962094
PMID:34355664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8354022/
Abstract

BACKGROUND

Skin, as a crucial external defense organ, is more vulnerable to oxidative stress (OS) insult, reactive oxygen species (ROS)-mediated OS in particular. OS results from a redox imbalance caused by various extrinsic stimuli and occurs once the oxidants production overwhelming the antioxidants capacity, through mediating in DNA damage, lipid peroxidation (LPO), protein oxidation and a serial of signaling pathways activation/inactivation, thereby offering favorable conditions for the occurrence and development of numerous diseases especially some dermatoses, e.g. psoriasis, vitiligo, skin photodamage, skin cancer, systemic sclerosis (SSc), chloasma, atopic dermatitis (AD), pemphigus, etc. Targeting OS molecular mechanism, a variety of anti-OS agents emerge, in which flavonoids, natural plant extracts, stand out.

OBJECTIVES

To discuss the possible mechanisms of OS mediating in dermatoses and summarize the properties of flavonoids as well as their applications in OS-related skin disorders.

METHODS

Published papers on flavonoids and OS-related skin diseases were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc.

RESULTS

It has been confirmed that flavonoids, belonging to polyphenols, are a class of plant secondary metabolites widely distributed in various plants and possess diverse bioactivities especially their potent antioxidant capacity. Moreover, flavonoids benefit to suppress OS via eliminating free radicals and mediating the corresponding signals, further excellently working in the prevention and management of OS-related skin diseases.

CONCLUSION

Flavonoids have the potential therapeutic effects on oxidative stress-related dermatoses. However, more studies on specific mechanism as well as the dosage of flavonoids are needed in future.

摘要

背景

皮肤作为重要的外部防御器官，更容易受到氧化应激（OS）的损伤，尤其是活性氧（ROS）介导的 OS。OS 是由各种外源性刺激引起的氧化还原失衡引起的，当氧化剂的产生超过抗氧化剂的能力时就会发生，通过介导 DNA 损伤、脂质过氧化（LPO）、蛋白质氧化和一系列信号通路的激活/失活，从而为许多疾病的发生和发展提供有利条件，特别是一些皮肤病，如银屑病、白癜风、皮肤光损伤、皮肤癌、系统性硬化症（SSc）、黄褐斑、特应性皮炎（AD）、天疱疮等。针对 OS 的分子机制，出现了各种抗氧化剂，其中黄酮类化合物、天然植物提取物尤为突出。

目的

探讨 OS 介导皮肤病的可能机制，并总结黄酮类化合物的特性及其在 OS 相关皮肤疾病中的应用。

方法

通过在 PubMed、MEDLINE 和 Embase 等数据库上搜索，收集并回顾了关于黄酮类化合物和 OS 相关皮肤疾病的已发表论文。

结果

已经证实，黄酮类化合物属于多酚类，是一类广泛存在于各种植物中的植物次生代谢物，具有多种生物活性，特别是其强大的抗氧化能力。此外，黄酮类化合物通过清除自由基和介导相应信号来抑制 OS，从而有利于防治 OS 相关的皮肤疾病。

结论

黄酮类化合物对氧化应激相关皮肤病具有潜在的治疗作用。然而，未来需要更多关于特定机制和黄酮类化合物剂量的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec9/8354022/3ac72b54f932/YRER_A_1962094_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec9/8354022/3c1bbf678346/YRER_A_1962094_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec9/8354022/3ac72b54f932/YRER_A_1962094_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec9/8354022/3c1bbf678346/YRER_A_1962094_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ec9/8354022/3ac72b54f932/YRER_A_1962094_F0002_OC.jpg

相似文献

1
Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses.目前有证据支持类黄酮在氧化应激相关皮肤病中的治疗潜力。
Redox Rep. 2021 Dec;26(1):134-146. doi: 10.1080/13510002.2021.1962094.
2
Antioxidant activity, lipid peroxidation and skin diseases. What's new.抗氧化活性、脂质过氧化与皮肤疾病。有哪些新进展。
J Eur Acad Dermatol Venereol. 2003 Nov;17(6):663-9. doi: 10.1046/j.1468-3083.2003.00751.x.
3
Flavonoids and their therapeutic applications in skin diseases.类黄酮及其在皮肤病中的治疗应用。
Arch Dermatol Res. 2023 Apr;315(3):321-331. doi: 10.1007/s00403-022-02395-3. Epub 2022 Sep 21.
4
Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants.植物酚类抗氧化剂和促氧化剂活性：植物中金属介导的酚类物质诱导的氧化损伤
Toxicology. 2002 Aug 1;177(1):67-80. doi: 10.1016/s0300-483x(02)00196-8.
5
Flavonoids as Promising Natural Compounds in the Prevention and Treatment of Selected Skin Diseases.类黄酮作为有前途的天然化合物在预防和治疗某些皮肤疾病中的应用。
Int J Mol Sci. 2023 Mar 28;24(7):6324. doi: 10.3390/ijms24076324.
6
Free radicals, metals and antioxidants in oxidative stress-induced cancer.氧化应激诱导癌症中的自由基、金属与抗氧化剂
Chem Biol Interact. 2006 Mar 10;160(1):1-40. doi: 10.1016/j.cbi.2005.12.009. Epub 2006 Jan 23.
7
Bamboo Leaf Flavonoids Extracts Alleviate Oxidative Stress in HepG2 Cells via Naturally Modulating Reactive Oxygen Species Production and Nrf2-Mediated Antioxidant Defense Responses.竹叶黄酮提取物通过自然调节活性氧产生和 Nrf2 介导的抗氧化防御反应减轻 HepG2 细胞氧化应激。
J Food Sci. 2019 Jun;84(6):1609-1620. doi: 10.1111/1750-3841.14609. Epub 2019 May 22.
8
Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review.玛氏油棕中黄酮类化合物的抗氧化作用与神经退行性疾病：文献综述
Cent Nerv Syst Agents Med Chem. 2019;19(2):75-99. doi: 10.2174/1871524919666190502105855.
9
Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease.线粒体诱导氧化应激，产生活性氧和眼睛晶状体的氧化还原状态失衡，导致人类白内障形成：磷脂氢过氧化物破坏晶状体的氧化还原组织，作为白内障疾病的共同基础。
Cell Biochem Funct. 2011 Apr;29(3):183-206. doi: 10.1002/cbf.1737. Epub 2011 Mar 7.
10
The promise of plant polyphenols as the golden standard skin anti-inflammatory agents.植物多酚有望成为皮肤抗炎的金标准药物。
Curr Drug Metab. 2010 Jun 1;11(5):414-24. doi: 10.2174/138920010791526033.

引用本文的文献

1
Identification of tomato F-box proteins functioning in phenylpropanoid metabolism.鉴定参与苯丙烷代谢的番茄 F-box 蛋白。
Plant Mol Biol. 2024 Jul 12;114(4):85. doi: 10.1007/s11103-024-01483-4.
2
Sirtuins in intervertebral disc degeneration: current understanding.Sirtuins 在椎间盘退变中的作用：研究现状。
Mol Med. 2024 Mar 29;30(1):44. doi: 10.1186/s10020-024-00811-0.
3
The Promising Role of Polyphenols in Skin Disorders.多酚在皮肤疾病中的大有可为的作用。

本文引用的文献

1
Luteolin attenuates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via suppression of inflammation response.木犀草素通过抑制炎症反应减轻咪喹莫特诱导的 BALB/c 小鼠银屑病样皮肤损伤。
Biomed Pharmacother. 2020 Nov;131:110696. doi: 10.1016/j.biopha.2020.110696. Epub 2020 Sep 10.
2
18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice.18β-甘草次酸通过 ROS 介导的 PI3K-Akt 信号通路诱导人 HaCaT 角质形成细胞凋亡，并改善咪喹莫特诱导的小鼠银屑病样皮肤损伤。
BMC Pharmacol Toxicol. 2020 Jun 3;21(1):41. doi: 10.1186/s40360-020-00419-0.
3
Molecules. 2024 Feb 15;29(4):865. doi: 10.3390/molecules29040865.
4
Stasis Dermatitis: Pathophysiology, Current Treatment Paradigms, and the Use of the Flavonoid Diosmin.淤积性皮炎：病理生理学、当前治疗模式及类黄酮地奥司明的应用
J Clin Aesthet Dermatol. 2024 Jan;17(1):15-23.
5
Protective Effects of var. Flower on Amyloid Beta-Treated C6 Glial Cells.变种花对β-淀粉样蛋白处理的C6神经胶质细胞的保护作用。
Life (Basel). 2023 Jun 27;13(7):1453. doi: 10.3390/life13071453.
6
Flavonoids as Promising Natural Compounds in the Prevention and Treatment of Selected Skin Diseases.类黄酮作为有前途的天然化合物在预防和治疗某些皮肤疾病中的应用。
Int J Mol Sci. 2023 Mar 28;24(7):6324. doi: 10.3390/ijms24076324.
7
Cellular senescence in skin-related research: Targeted signaling pathways and naturally occurring therapeutic agents.皮肤相关研究中的细胞衰老：靶向信号通路和天然治疗剂。
Aging Cell. 2023 Jun;22(6):e13845. doi: 10.1111/acel.13845. Epub 2023 Apr 11.
8
Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications.基于皮肤应用对欧洲常见树木树皮提取物的抗氧化和抗菌评估。
Antibiotics (Basel). 2023 Jan 9;12(1):130. doi: 10.3390/antibiotics12010130.
9
The role of oxidative stress in intervertebral disc cellular senescence.氧化应激在椎间盘细胞衰老中的作用。
Front Endocrinol (Lausanne). 2022 Dec 6;13:1038171. doi: 10.3389/fendo.2022.1038171. eCollection 2022.
10
Natural Antioxidants, Tyrosinase and Acetylcholinesterase Inhibitors from Leaves.天然抗氧化剂、酪氨酸酶和乙酰胆碱酯酶抑制剂来源于树叶。
Molecules. 2022 Dec 7;27(24):8667. doi: 10.3390/molecules27248667.
An isoflavone extract from soybean cake suppresses 2,4-dinitrochlorobenzene-induced contact dermatitis.
大豆饼粕异黄酮提取物抑制 2,4-二硝基氯苯诱导的接触性皮炎。
J Ethnopharmacol. 2020 Dec 5;263:113037. doi: 10.1016/j.jep.2020.113037. Epub 2020 May 30.
4
Juglanin administration protects skin against UVB‑induced injury by reducing Nrf2‑dependent ROS generation.Juglanin 给药通过减少 Nrf2 依赖性 ROS 生成来保护皮肤免受 UVB 诱导的损伤。
Int J Mol Med. 2020 Jul;46(1):67-82. doi: 10.3892/ijmm.2020.4589. Epub 2020 Apr 24.
5
Cistanche deserticola polysaccharide induces melanogenesis in melanocytes and reduces oxidative stress via activating NRF2/HO-1 pathway.肉苁蓉多糖通过激活 NRF2/HO-1 通路诱导黑素细胞中的黑色素生成并减少氧化应激。
J Cell Mol Med. 2020 Apr;24(7):4023-4035. doi: 10.1111/jcmm.15038. Epub 2020 Feb 25.
6
Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression.紫外线相关皮肤癌和发育异常病变中的蛋白质氧化损伤促进肿瘤发生和进展。
Cancers (Basel). 2020 Jan 1;12(1):110. doi: 10.3390/cancers12010110.
7
Nrf2 Overexpression for the Protective Effect of Skin-Derived Precursors against UV-Induced Damage: Evidence from a Three-Dimensional Skin Model.Nrf2 过表达对皮肤来源前体细胞对抗 UV 诱导损伤的保护作用：来自三维皮肤模型的证据。
Oxid Med Cell Longev. 2019 Oct 14;2019:7021428. doi: 10.1155/2019/7021428. eCollection 2019.
8
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis.活性氧诱导的细胞凋亡、自噬和铁死亡中的脂质过氧化作用。
Oxid Med Cell Longev. 2019 Oct 13;2019:5080843. doi: 10.1155/2019/5080843. eCollection 2019.
9
Ginsenoside Rg1 abolish imiquimod-induced psoriasis-like dermatitis in BALB/c mice via downregulating NF-κB signaling pathway.人参皂苷 Rg1 通过下调 NF-κB 信号通路来消除咪喹莫特诱导的 BALB/c 小鼠银屑病样皮炎。
J Food Biochem. 2019 Nov;43(11):e13032. doi: 10.1111/jfbc.13032. Epub 2019 Sep 9.
10
Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation.红景天苷通过激活 SIRT1 抑制银屑病相关氧化应激中的 MAPK、NF-κB 和 STAT3 通路。
Redox Rep. 2019 Dec;24(1):70-74. doi: 10.1080/13510002.2019.1658377.