Ho Tzu-Chuan, Chang Chin-Chuan, Chan Hung-Pin, Huang Ying-Fong, Chen Yi-Ming Arthur, Chuang Kuo-Pin, Lee Che-Hsin, Yuan Cheng-Hui, Deng Yu-Zhen, Yang Ming-Hui, Tyan Yu-Chang
Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Pathogens. 2021 Jul 3;10(7):839. doi: 10.3390/pathogens10070839.
During the coronavirus disease 2019 (COVID-19) pandemic, several case studies demonstrated that many asymptomatic patients with COVID-19 underwent fluorine-18 fluorodeoxyglucose ([F]FDG) positron emission tomography/computed tomography (PET/CT) examination for various indications. However, there is a lack of literature to characterize the pattern of [F]FDG PET/CT imaging on asymptomatic COVID-19 patients. Therefore, a systematic review to analyze the pulmonary findings of [F]FDG PET/CT on asymptomatic COVID-19 patients was conducted. This systematic review was performed under the guidelines of PRISMA. PubMed, Medline, and Web of Science were used to search for articles for this review. Articles with the key words: "asymptomatic", "COVID-19", "[F]FDG PET/CT", and "nuclear medicine" were searched for from 1 January 2020 to 20 May 2021. Thirty asymptomatic patients with COVID-19 were included in the eighteen articles. These patients had a mean age of 62.25 ± 14.85 years (male: 67.71 ± 12.00; female: 56.79 ± 15.81). [F]FDG-avid lung lesions were found in 93.33% (28/30) of total patients. The major lesion was [F]FDG-avid multiple ground-glass opacities (GGOs) in the peripheral or subpleural region in bilateral lungs, followed by the consolidation. The intensity of [F]FDG uptake in multiple GGOs was 5.605 ± 2.914 (range from 2 to 12) for maximal standardized uptake value (SUVmax). [F]FDG-avid thoracic lymph nodes (LN) were observed in 40% (12/40) of the patients. They mostly appeared in both mediastinal and hilar regions with an SUVmax of 5.8 ± 2.93 (range from 2.5 to 9.6). The [F]FDG uptake was observed in multiple GGOs, as well as in the mediastinal and hilar LNs. These are common patterns in PET/CT of asymptomatic patients with COVID-19.
在2019冠状病毒病（COVID-19）大流行期间，多项病例研究表明，许多无症状的COVID-19患者因各种指征接受了氟-18氟脱氧葡萄糖（[F]FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）检查。然而，缺乏文献来描述无症状COVID-19患者的[F]FDG PET/CT成像模式。因此，进行了一项系统评价，以分析无症状COVID-19患者[F]FDG PET/CT的肺部表现。本系统评价按照PRISMA指南进行。使用PubMed、Medline和科学网搜索本评价的文章。从2020年1月1日至2021年5月20日搜索关键词为“无症状”、“COVID-19”、“[F]FDG PET/CT”和“核医学”的文章。18篇文章纳入了30例无症状COVID-19患者。这些患者的平均年龄为62.25±14.85岁（男性：67.71±12.00；女性：56.79±15.81）。93.33%（28/30）的患者发现有[F]FDG摄取阳性的肺部病变。主要病变为双侧肺外周或胸膜下区域[F]FDG摄取阳性的多发磨玻璃影（GGO），其次为实变。多发GGO的[F]FDG摄取强度，最大标准化摄取值（SUVmax）为5.605±2.914（范围为2至12）。40%（12/40）的患者观察到[F]FDG摄取阳性的胸部淋巴结（LN）。它们大多出现在纵隔和肺门区域，SUVmax为5.8±2.93（范围为2.5至9.6）。在多发GGO以及纵隔和肺门LN中均观察到[F]FDG摄取。这些是无症状COVID-19患者PET/CT的常见表现。
