Department of Oral Medicine, Medical University of Lublin, ul. Chodźki 6, 20-093 Lublin, Poland.
Int J Environ Res Public Health. 2021 Aug 2;18(15):8193. doi: 10.3390/ijerph18158193.
A number of systemic diseases including hematological disorders have manifestations in the oral cavity region. These manifestations may often represent early signs of the underlying hematopoietic disease and occur frequently in leukemia. Despite the fact that leukemia has long been known to be associated with oral health deterioration, the available literature on this topic consists mostly of case reports, without data to conclude these. The aim of the study was to assess dentition state in leukemic patients during one cycle of chemotherapy and its correlation with blood parameters. The study included 102 adults treated because of leukemia at the Clinic of Haemato-Oncology and Bone Marrow Transplantation at the university hospital in Lublin, Poland. The sample group consisted of 51 women and 51 men aged 22 to 72 (54.07 ± 10.33) with following diagnoses: Acute myelogenous leukemia (AML)-55 patients (53.92%), Chronic lymphocytic leukemia (CLL)-17 patients (16.67%), Acute lymphoblastic leukemia (ALL)-16 patients (15.69%), Chronic myelogenous leukemia (CML)-10 patients (9.80%), Acute promyelocytic leukemia (APL) -3 patients (2.94%), Chronic hairy cell leukemia (HCL)-1 patient (0.98%). DMFT index was used to assess dentition state. After the cycle of chemotherapy, their dentition state changed in terms of decayed, missing and filled teeth and correlated with hematological parameters. Adult patients with leukemia have high dental treatment needs, and high number of missing teeth; thus, a comprehensive and fast dental treatment is necessary to avoid systemic complications and ensure better quality of life.
一些系统性疾病，包括血液系统疾病，在口腔区域有表现。这些表现可能经常代表潜在造血疾病的早期迹象，并且在白血病中经常发生。尽管白血病早已被认为与口腔健康恶化有关，但关于这个主题的可用文献主要由病例报告组成，没有数据得出这些结论。本研究旨在评估白血病患者在一个化疗周期中的牙齿状况及其与血液参数的相关性。该研究纳入了 102 名在波兰卢布林大学医院血液肿瘤学和骨髓移植科接受治疗的成年人，其中包括 51 名女性和 51 名男性，年龄 22 至 72 岁（54.07 ± 10.33），诊断如下：急性髓细胞性白血病（AML）-55 例（53.92%）、慢性淋巴细胞性白血病（CLL）-17 例（16.67%）、急性淋巴细胞性白血病（ALL）-16 例（15.69%）、慢性髓细胞性白血病（CML）-10 例（9.80%）、急性早幼粒细胞白血病（APL）-3 例（2.94%）、慢性毛细胞白血病（HCL）-1 例（0.98%）。使用 DMFT 指数评估牙齿状况。在化疗周期后，他们的牙齿状况在龋齿、缺失和填充牙齿方面发生了变化，并与血液学参数相关。白血病成年患者有很高的牙齿治疗需求，并且有大量的缺牙，因此需要进行全面快速的牙齿治疗，以避免全身并发症并确保更好的生活质量。
