World-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Department of Bioelementology, KG Razumovsky Moscow State University of Technologies and Management, 109004 Moscow, Russia.
Int J Environ Res Public Health. 2021 Aug 3;18(15):8195. doi: 10.3390/ijerph18158195.
The objective of the present study was to evaluate hair toxic metal levels in patients with obesity and/or coronary heart disease (CHD). Following a 2 × 2 factorial design, subjects without CHD were grouped into normal weight control ( = 123) and obese groups ( = 140). Patients suffering from CHD were divided into normal weight ( = 180) and obese CHD subjects ( = 240). Hair Al, As, Cd, Hg, Ni, and Pb levels were evaluated using inductively-coupled plasma mass-spectrometry. The data demonstrate that hair Al and Hg levels were higher in obese subjects as compared to normal weight controls. Normal weight CHD patients were characterized by significantly higher hair Al, As, Cd, and Pb levels when compared to healthy subjects. The highest hair Al, As, and Pb levels were observed in obese CHD patients, significantly exceeding the respective values in other groups. Factorial analysis revealed significant influence of factorial interaction (CHD*obesity) only for hair Pb content. Given the role of obesity as a risk factor for CHD, it is proposed that increased toxic metal accumulation in obesity may promote further development of cardiovascular diseases.
本研究旨在评估肥胖症和/或冠心病（CHD）患者的毛发中有毒金属水平。采用 2×2 析因设计，无 CHD 的受试者分为正常体重对照组（n=123）和肥胖组（n=140）。患有 CHD 的患者分为正常体重组（n=180）和肥胖型 CHD 组（n=240）。采用电感耦合等离子体质谱法评估毛发中的 Al、As、Cd、Hg、Ni 和 Pb 水平。数据表明，与正常体重对照组相比，肥胖组的毛发 Al 和 Hg 水平更高。与健康受试者相比，正常体重的 CHD 患者的毛发 Al、As、Cd 和 Pb 水平显著更高。在肥胖型 CHD 患者中观察到最高的毛发 Al、As 和 Pb 水平，显著超过其他组的相应值。析因分析显示，仅在毛发 Pb 含量方面存在 CHD*肥胖的因子交互作用的显著影响。鉴于肥胖是 CHD 的一个危险因素，因此可以认为，肥胖症中有毒金属的积累增加可能会促进心血管疾病的进一步发展。
