Penttilä I M, Herranen J, Lampainen E, Voutilainen E
Department of Clinical Chemistry, University of Kuopio, Finland.
Clin Chim Acta. 1987 Dec;170(2-3):143-9. doi: 10.1016/0009-8981(87)90122-7.
According to the present study, in hyperlipidemias where triglyceride values in serum are raised, the triglyceride values are associated with increased amounts of branched-chain alpha-keto-acids (BCKA) in the serum. In particular, the concentration of alpha-ketoisocaproic acid (KICA), which in the control sera was 34.4 mumol/l, was in type IIB hyperlipidemia 40.4% and in type IV 49.4% higher than in controls with normal serum lipid values. In type IV hyperlipidemia, values for alpha-ketoisovaleric acid (KIVA) and alpha-keto-beta-methyl-n-valeric acid (KMVA) were also high when compared to the corresponding mean values of the controls, 7.1 and 18.8 mumol/l. The respective differences were 57.7 and 44.1 per cent. In type IIB hyperlipidemia, KIVA was significantly and KMVA insignificantly increased compared to the control group. In type IIA hyperlipidemia with normal triglyceride values, none of the three BCKA differed significantly from the controls. These results also indicate that the increased amounts of individual BCKA somehow depend on the concentration of triglycerides in serum, while no relationship was found between BCKA values and cholesterol concentration.
根据本研究，在血清甘油三酯值升高的高脂血症中，血清甘油三酯值与血清中支链α-酮酸（BCKA）含量增加有关。特别是，α-酮异己酸（KICA）在对照血清中的浓度为34.4μmol/L，在IIB型高脂血症中比血脂正常的对照高40.4%，在IV型中高49.4%。在IV型高脂血症中，与对照的相应平均值7.1和18.8μmol/L相比，α-酮异戊酸（KIVA）和α-酮-β-甲基-n-戊酸（KMVA）的值也较高。各自的差异分别为57.7%和44.1%。在IIB型高脂血症中，与对照组相比，KIVA显著增加，KMVA无显著增加。在甘油三酯值正常的IIA型高脂血症中，三种BCKA均与对照组无显著差异。这些结果还表明，个体BCKA含量的增加在某种程度上取决于血清中甘油三酯的浓度，而BCKA值与胆固醇浓度之间未发现相关性。
