吲哚美辛不同药物制剂对类风湿性关节炎患者夜间疼痛和晨僵的影响。
The effects of differing pharmaceutical preparations of indomethacin on night pain and morning stiffness in patients with rheumatoid arthritis.
作者信息
Vasanthakumar V, Haslock I
机构信息
Rheumatology Unit, Middlesborough General Hospital, England.
出版信息
Curr Med Res Opin. 1987;10(9):592-5. doi: 10.1185/03007998709112412.
A study was carried out in 18 patients with rheumatoid arthritis to compare the effects of two different preparations of indomethacin with placebo on night pain, sleep and duration of morning stiffness. Patients were treated for 1 night each, in random order, with identical capsules containing 75 mg indomethacin, either as 'Indomod' (all sustained-release form) or 'Indocid' R (25 mg normal, 50 mg sustained-release form), or placebo as a substitute for their usual night-time medication. The results of visual analogue scale scores and a standard sleep assessment questionnaire score indicated the same order of effectiveness for each of the three parameters, with 'Indomod' best, 'Indocid' R intermediate and placebo worst, but only the difference in sleep was statistically significant. 'Indomod', therefore, might offer a slight advantage over the same dose of indomethacin as 'Indocid' R given at night. Less side-effects were produced by active treatment than by placebo and none was severe.
对18名类风湿性关节炎患者进行了一项研究，以比较两种不同剂型的吲哚美辛与安慰剂对夜间疼痛、睡眠及晨僵持续时间的影响。患者每晚接受一次治疗，随机服用含有75毫克吲哚美辛的相同胶囊，剂型分别为“Indomod”（全缓释剂型）或“Indocid”R（25毫克普通剂型，50毫克缓释剂型），或用安慰剂替代其常用的夜间药物。视觉模拟量表评分和标准睡眠评估问卷评分结果表明，三个参数的有效性顺序相同，“Indomod”最佳，“Indocid”R次之，安慰剂最差，但只有睡眠方面的差异具有统计学意义。因此，与夜间服用相同剂量的“Indocid”R相比，“Indomod”可能具有轻微优势。与安慰剂相比，活性治疗产生的副作用更少，且均不严重。
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