Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 4545, Saudi Arabia.
Molecules. 2021 Jul 23;26(15):4456. doi: 10.3390/molecules26154456.
The use of copaiba oil has been reported since the 16th century in Amazon traditional medicine, especially as an anti-inflammatory ingredient and for wound healing. The use of copaiba oil continues today, and it is sold in various parts of the world, including the United States. Copaiba oil contains mainly sesquiterpenes, bioactive compounds that are popular for their positive effect on human health. As part of our ongoing research endeavors to identify the chemical constituents of broadly consumed herbal supplements or their adulterants, copaiba oil was investigated. In this regard, copaiba oil was subjected to repeated silica gel column chromatography to purify the compounds. As a result, one new and seven known sesquiterpenes/sesquiterpenoids were isolated and identified from the copaiba oil. The new compound was elucidated as ()-2,6,10-trimethyldodec-8-en-2-ol. Structure elucidation was achieved by 1D- and 2D NMR and GC/Q-ToF mass spectral data analyses. The isolated chemical constituents in this study could be used as chemical markers to evaluate the safety or quality of copaiba oil.
库帕亚油自 16 世纪以来就在亚马逊传统医学中被使用，特别是作为一种抗炎成分和用于伤口愈合。库帕亚油的使用一直延续到今天，并且在世界上的许多地方都有销售，包括美国。库帕亚油主要含有倍半萜烯，这些生物活性化合物因其对人类健康的积极影响而广受欢迎。作为我们正在进行的研究工作的一部分，旨在确定广泛消费的草药补充剂或其掺杂物的化学成分，我们对库帕亚油进行了研究。在这方面，库帕亚油经过反复的硅胶柱层析来纯化化合物。结果，从库帕亚油中分离并鉴定出一种新的和七种已知的倍半萜烯/倍半萜类化合物。新化合物被阐明为（）-2,6,10-三甲基十二烷-8-烯-2-醇。结构阐明是通过 1D 和 2D NMR 和 GC/Q-ToF 质谱数据分析完成的。本研究中分离出的化学成分可用作化学标志物来评估库帕亚油的安全性或质量。
