与甲麻黄碱同时使用的精神活性物质及丙型肝炎病毒感染
Psychoactive Substances Taken with Mephedrone and HCV Infection.
作者信息
Ordak Michal, Nasierowski Tadeusz, Muszynska Elzbieta, Bujalska-Zadrozny Magdalena
机构信息
Department of Pharmacodynamics, Centre for Preclinical, Research and Technology (CePT), Medical University of Warsaw, 02-091 Warsaw, Poland.
Department of Psychiatry, Medical University of Warsaw, 02-091 Warsaw, Poland.
出版信息
J Clin Med. 2021 Jul 21;10(15):3218. doi: 10.3390/jcm10153218.
BACKGROUND
In recent years, the observed frequency of hospitalization of patients taking mephedrone with other psychoactive substances has increased. There are no data in the literature on the effect of mephedrone use on liver function in patients, including the frequency of HCV infection. We have analysed the impact of taking mephedrone together with other psychoactive substances on the incidence of HCV infection. We have also analysed the effect of taking mephedrone with heroin, alcohol, and benzodiazepines on liver enzyme levels.
METHODS
The study included patients taking mephedrone with: alcohol ( = 115), heroin ( = 85) and benzodiazepines ( = 130) hospitalized in 2010-2018. The control group consisted of patients addicted to alcohol ( = 180), heroin ( = 221) and benzodiazepines ( = 152). Clinical data and laboratory findings were collected from medical records.
RESULTS
Taking mephedrone together with benzodiazepines is a statistically significant predictor of HCV infection in this group of patients, OR (8.44); 95% CI 5.63-12.64; < 0.001). A statistically significant interaction of the group with HCV infection was observed, i.e., for the level of alanine transaminase ( < 0.001) and aspartate transaminase ( < 0.001). Increased levels of liver enzymes in each of the studied groups was characteristic in patients with HCV infection ( < 0.001). Taking additional mephedrone by this group of patients did not increase the level of liver enzymes.
CONCLUSION
HCV infection is a statistically significant factor affecting the increase in liver enzymes levels in the group of patients taking mephedrone.
背景
近年来，服用甲麻黄碱及其他精神活性物质的患者住院频率有所增加。文献中尚无关于甲麻黄碱使用对患者肝功能影响的数据，包括丙型肝炎病毒（HCV）感染频率。我们分析了同时服用甲麻黄碱及其他精神活性物质对HCV感染发生率的影响。我们还分析了同时服用甲麻黄碱与海洛因、酒精和苯二氮䓬类药物对肝酶水平的影响。
方法
该研究纳入了2010年至2018年期间住院的同时服用甲麻黄碱与酒精（n = 115）、海洛因（n = 85）和苯二氮䓬类药物（n = 130）的患者。对照组由酒精成瘾（n = 180）、海洛因成瘾（n = 221）和苯二氮䓬类药物成瘾（n = 152）的患者组成。从病历中收集临床数据和实验室检查结果。
结果
在该组患者中，同时服用甲麻黄碱和苯二氮䓬类药物是HCV感染的统计学显著预测因素，比值比（OR）为8.44；95%置信区间为5.63 - 12.64；P < 0.001）。观察到该组与HCV感染之间存在统计学显著的相互作用，即丙氨酸转氨酶水平（P < 0.001）和天冬氨酸转氨酶水平（P < 0.001）。在每个研究组中，HCV感染患者的肝酶水平升高具有特征性（P < 0.001）。该组患者额外服用甲麻黄碱并未增加肝酶水平。
结论
在服用甲麻黄碱的患者组中，HCV感染是影响肝酶水平升高的统计学显著因素。
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